14703-82-3

Basic information

• Product Name: N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine
• Synonyms: N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine;3-methoxy-N,N-dimethyl-4-nitroaniline
• CAS NO: 14703-82-3
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.21
• Mol File: 14703-82-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-126°
• Boiling Point: 327.9°Cat760mmHg
• Flash Point: 152.1°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 0.000196mmHg at 25°C
• Refractive Index: 1.572
• PKA: 0.29±0.22(Predicted)
• CAS DataBase Reference: N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine(14703-82-3)
• EPA Substance Registry System: N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine(14703-82-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14703-82-3(Hazardous Substances Data)

Usage

General Description

N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine is a chemical compound with the molecular formula C10H14N2O3. It is a pale yellow solid that is soluble in organic solvents. N-(3-methoxy-4-nitrophenyl)-N,N-dimethylamine is commonly used as an intermediate in the synthesis of pharmaceuticals and dyes. It is also known for its ability to act as a photosensitizer in photodynamic therapy, a treatment for cancer and other diseases. The presence of a nitro group in the molecule makes it useful in organic synthesis, as it can undergo various chemical reactions to produce a wide range of derivatives with different properties and applications. However, it is important to handle this compound with caution, as it is potentially harmful if ingested, inhaled, or if it comes into contact with the skin.

InChI:InChI=1/C9H12N2O3/c1-10(2)7-4-5-8(11(12)13)9(6-7)14-3/h4-6H,1-3H3

Upstream product

• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 124-40-3 dimethyl amine 

Downstream Products

• 7474-82-0 3-methoxy-N¹,N¹-dimethylbenzene-1,4-diamine 

Relevant articles and documents

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer

NUAK, the member of AMPK (AMP-activated protein kinase) family of protein kinases, is phosphorylated and activated by the LKB1 (liver kinase B1) tumor suppressor protein kinase. Recent work has indicated that NUAK1 is a key component of the antioxidant stress response pathway, and the inhibition of NUAK1 will suppress the growth and survival of colorectal tumors. As a promising target for anticancer drugs, few inhibitors of NUAK were developed. With this goal in mind, based on NUAK inhibitor WZ4003, a series of derivatives has been synthesized and evaluated for anticancer activity. Compound 9q, a derivative of WZ4003 by removing a methoxy group, was found to be the most potential one with stronger inhibitory against NUAK1/2 enzyme activity, tumor cell proliferation and inducing apoptosis of tumor cells. By in vivo efficacy evaluations of colorectal SW480 xenografts, 9q suppresses tumor growth more effectively with an excellent safety profile in vivo and is therefore seen as a suitable candidate for further investigation.

PYRIMIDINE INHIBITORS OF KINASE ACTIVITY

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-IR.