147081-85-4

Basic information

• Product Name: 4-(1H-Imidazol-1-yl)piperidine
• Synonyms: 4-IMIDAZOL-1-YL-PIPERIDINE HCL;Piperidine, 4-(1H-imidazol-1-yl)-;4-(1H-imidazol-1-yl)piperidine;4-IMIDAZOL-1-YL-PIPERIDINE;4-(1H-imidazol-1-yl)piperidine HCl
• CAS NO: 147081-85-4
• Molecular Formula: C₈H₁₃N₃
• Molecular Weight: 151.21
• Product Categories: Piperidine
• Mol File: 147081-85-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 330.234 °C at 760 mmHg
• Flash Point: 153.52 °C
• Appearance: Gray-white power
• Density: 1.216 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.39±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-Imidazol-1-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-Imidazol-1-yl)piperidine(147081-85-4)
• EPA Substance Registry System: 4-(1H-Imidazol-1-yl)piperidine(147081-85-4)

Safety Data

• Hazardous Substances Data: 147081-85-4(Hazardous Substances Data)

Usage

General Description

4-(1H-Imidazol-1-yl)piperidine, also known as 1-(1H-imidazol-1-yl)piperidine, is a chemical compound with the molecular formula C8H15N3. It is a heterocyclic compound with a piperidine ring and an imidazole ring. 4-(1H-Imidazol-1-yl)piperidine is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals, especially those targeting the central nervous system. It has also been studied for its potential use as a ligand in the development of new drug candidates. Additionally, 4-(1H-Imidazol-1-yl)piperidine may have applications in other fields such as organic synthesis and chemical research.

InChI:InChI=1/C8H13N3/c1-3-9-4-2-8(1)11-6-5-10-7-11/h5-9H,1-4H2

Upstream product

• 158654-89-8 4-imidazol-1-yl-piperidine-1-carboxylic acid tert-butyl ester 
• 1120-87-2 4-bromopyridin 
• 25700-16-7 1-(pyridin-4-yl)-1H-imidazole 

Downstream Products

• 1208254-45-8 N-(5-tert-butyl-2-methylphenyl)-2-[4-(1H-imidazol-1-yl)piperidin-1-yl]-7-methyl-7H-purin-6-amine 

Relevant articles and documents

A convenient synthesis of (1 H-azol-1-yl)piperidines

A convenient preparation of 3- and 4-(1H-azol-1-yl)piperidines by arylation of azoles (i.e., pyrazoles, imidazoles, and triazoles) with 3- and 4-bromopyridines and subsequent reduction of the pyridine ring was developed. The method was extended to benzo analogues of the title compounds. Georg Thieme Verlag Stuttgart · New York.

CHEMICAL COMPOUNDS

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the

Method of treating cancer using FPT inhibitors and antineoplastic agents

Disclosed is a method of treating cancer in a patient in need of such treatment comprising administering a therapeutically effective amount of an FPT inhibitor and therapeutically effective amounts of one or more antineoplastic agents. Methods of treating non small cell lung cancer, squamous cell cancer of the head and neck, CML, AML, non-Hodgkin's lymphoma and multiple myeloma are disclosed.