147098-18-8

Basic information

• Product Name: Rosuvastatin sodium
• Synonyms: ROSUVASTATIN SODIUM;7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid sodium salt;7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid;CRESTOR;ROSUVASTATIN CA;ROSUVASTATIN, CALCIUM SALT
• CAS NO: 147098-18-8
• Molecular Formula: C44H54CaF2N6O12S2
• Molecular Weight: 503.52
• EINECS: 1806241-263-5
• Product Categories: Rosuvastatin Calcium and its intermediates
• Mol File: 147098-18-8.mol
• Article Data: 0

Chemical Properties

• Appearance: Colorless or yellowish liquid
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Rosuvastatin sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Rosuvastatin sodium(147098-18-8)
• EPA Substance Registry System: Rosuvastatin sodium(147098-18-8)

Safety Data

• Hazardous Substances Data: 147098-18-8(Hazardous Substances Data)

Usage

Description

Rosuvastatin sodium is a synthetic lipid-lowering medication belonging to the class of statins. It functions by inhibiting the enzyme HMG-CoA reductase, which is essential for the body's production of cholesterol. This action leads to a reduction in low-density lipoprotein (LDL) levels, triglycerides, and an increase in high-density lipoprotein (HDL) levels, making it a valuable treatment for various cardiovascular conditions.

Uses

Used in Pharmaceutical Industry:
Rosuvastatin sodium is used as a pharmaceutical agent for the treatment of hyperlipidemia, a condition characterized by elevated levels of cholesterol and triglycerides in the blood. It helps in reducing the risk of cardiovascular diseases such as heart attacks and strokes by effectively managing lipid profiles.
Used in Research and Development:
Rosuvastatin sodium is also utilized in the research and development of new drugs and therapies related to cardiovascular health. Its role in inhibiting HMG-CoA reductase makes it a valuable compound for studying the mechanisms of cholesterol synthesis and the development of novel treatments for related conditions.
Used in Preparation of Intermediate Compounds:
Rosuvastatin sodium is used as a precursor in the preparation of rosuvastatin calcium, an intermediate compound in the synthesis of the final drug product. This intermediate is crucial for the production of the active pharmaceutical ingredient (API) used in the formulation of rosuvastatin calcium tablets or capsules.

InChI:InChI=1/C22H28FN3O6S.Na/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;+1/p-1/b10-9+;