147198-49-0Relevant articles and documents
Palladium-catalyzed mono-γ-arylation of 7-methoxy-4-methylcoumarin
Sexton, Mary E.,Okazaki, Ami,Yu, Zhuowen,van Venrooy, Alexis,Schmink, Jason R.,Malachowski, William P.
, (2019)
Herein, we report the selective mono-γ-arylation of 7-methoxy-4-methylcoumarin under palladium-catalyzed conditions. The Buchwald G3 pre-catalyst in conjunction with either the Xantphos or N-Xantphos ligand proves to be highly reactive, engaging aryl iodides, bromides, chlorides, and triflates to effect the desired transformation. A wide range of functionality is tolerated, including the ability to activate heteroaryl halides in the transformation. The initial scope of aryl halides and limitations of this methodology are presented.