1472-62-4

Basic information

• Product Name: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-
• Synonyms: (+/-)-1-(4-Hydroxy-benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isochinolin-7-ol;rac-N-Methyl-coclaurin,(+/-)-1-(p-Hydroxy-benzyl)-2-methyl-6-methoxy-7-hydroxy-1,2,3,4-tetrahydro-isochinolin;(+/-)-N-methylcoclaurine;1-(4-hydroxy-benzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol
• CAS NO: 1472-62-4
• Molecular Formula: C18H21NO3
• Molecular Weight: 299.37
• Mol File: 1472-62-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-(1472-62-4)
• EPA Substance Registry System: 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-(1472-62-4)

Safety Data

• Hazardous Substances Data: 1472-62-4(Hazardous Substances Data)

Usage

General Description

7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl- is a chemical compound with the molecular formula C19H23NO3. It is a derivative of isoquinoline and contains a tetrahydro-1,4-benzodioxin ring structure. 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl- has been studied for its potential pharmacological properties, including its anti-inflammatory and antioxidant effects. It has also been investigated for its potential use in the treatment of various diseases, including cancer. Studies have shown that this compound may have anti-tumor and anti-proliferative activities, making it a potentially interesting molecule for further research and development in the field of medicinal chemistry.

Upstream product

• 121813-66-9 7-benzyloxy-1-(4-benzyloxy-benzyl)-6-methoxy-2-methyl-3,4-dihydro-isoquinolinium; iodide 
• 50-00-0 formaldehyd 
• 123-08-0 4-hydroxy-benzaldehyde 
• 50262-54-9 ethyl (4-formylphenyl) carbonate 
• 77410-37-8 longifolonine 
• 2033-08-1 coclaurine 
• 5990-67-0 d-tetrandrine 
• 80955-38-0 7-Hydroxy-1-(4-hydroxy-benzyl)-6-methoxy-2-methyl-3,4-dihydro-isoquinolinium 
• 67-56-1 methanol 

Downstream Products

• 1934-93-6 6,7-dimethoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 477-57-6 (+)-isotetrandrine 
• 72142-82-6 1,2-didehydrocoripallinium ion 
• 123-08-0 4-hydroxy-benzaldehyde 
• 80955-38-0 7-Hydroxy-1-(4-hydroxy-benzyl)-6-methoxy-2-methyl-3,4-dihydro-isoquinolinium 
• 38474-22-5 (+/-)-<3',5',8-3H3>N-methyl-coclaurine 
• 17127-48-9 N-methylcrotsparine 
• 450-14-6 6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 72142-83-7 2-Methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,10,11-triol 

Relevant articles and documents

Isolation and preparation of 3H-tetrandrine

Tetrandrine is a biabenzytehahydroisoquinoline alkaloid. Its structure is vary complex and the preparation of labeled derivatives is difficult. We have prepared 3H-tatrandrine using the tritium gas exposure method. This method produces many fragments which make isolation and purification of small quantities difficult. We investigated these fragments of unlabeled d-tetrandrine and found almost all contain one to several hydroxide groups. Using this information, we designed a two-step paper chromatography method for isolation and purification of 3H-Tetrandrine. This method involves the application of a pH 4.7 Na2HPO4-citric acid buffer to the paper to block the migration of hydroxide group fragments of tetrandrine. 3H-tetrandrine was successfully with a radiochemical purity of 90%.

Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro

Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)-N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5′-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships. Georg Thieme Verlag KG Stuttgart.

Alkaloids of Cryptocarya longifolia: X-ray Crystal Structure of Thalifoline and Longifolonine

The known alkaloids reticuline (1), coclaurine (3), N-methylcoclaurine (2), laurotetanine (7), N-methyllaurotetanine (8), laurolitsine (10), isoboldine (9), norisocorydine (6), norargemonine (11), bisnorargemonine (12), thalifoline (16) and scoulerine (13) were isolated from the New Caledonian plant Cryptocarya longifolia together with two new bases, longifolidine (4) and longifolonine (14).Spectroscopic methods were used for identification and structural investigation, and X-ray crystallographic analysis to determine the structures of thialifoline and longifolonine