14720-33-3Relevant articles and documents
The triple role of fluoride ions in palladium-catalyzed Suzuki-Miyaura reactions: Unprecedented transmetalation from [ArPdFL2] complexes
Amatore, Christian,Jutand, Anny,Leduc, Gaatan
, p. 1379 - 1382 (2012)
Fluoride ions play three roles in the Suzuki-Miyaura reaction. They favor the reaction by formation of trans-[ArPdF(PPh3)2], which reacts with Ar B(OH)2 in an unprecedented rate-determining transmetalation, and by promoting the reductive elimination from the trans-[ArPdAr (PPh3)2] intermediate. Conversely, F - disfavors the reaction by formation of unreactive anionic Ar B(OH)n-3Fn- (n=1-3), leading to two antagonistic effects of F- in the transmetalation. Copyright