147385-61-3

Basic information

• Product Name: LEUPEPTIN TRIFLUOROACETATE SALT
• Synonyms: LEUPEPTIN TRIFLUOROACETATE SALT;ACETYL-LEU-LEU-ARG-AL TRIFLUOROACETATE SALT;LEUPEPTIN TRIFLUOROACETATE FROM*MICROBIA L SOURCE;leupeptintrifluoroacetatesalt90+%;Leupeptin trifluoroacetate salt,Acetyl-Leu-Leu-Arg-al trifluoroacetate salt
• CAS NO: 147385-61-3
• Molecular Formula: C22H39F3N6O6
• Molecular Weight: 540.58
• Product Categories: αA to C;alpha-;Apoptosis Enzymes;Application Index;Calpain II;Calpain II Inhibitors;Cathepsin B;Cathepsin H;Cathepsin/Granzyme Inhibitors &Cell Signaling Enzymes;Coagulation Proteins and Reagents;D to K;Endoproteinase Lys-C;General Inhibitors;Kallikrein tissue;-;Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Calpain;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Chymotrypsin;Core Bioreagents;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;L;Lys;Substrates;inhibitor
• Mol File: 147385-61-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 775.4°C at 760 mmHg
• Flash Point: 422.7°C
• Appearance: /
• Vapor Pressure: 2.41E-26mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: H2O: 10 mM Solutions are stable only a few hours. Stock sol
• CAS DataBase Reference: LEUPEPTIN TRIFLUOROACETATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: LEUPEPTIN TRIFLUOROACETATE SALT(147385-61-3)
• EPA Substance Registry System: LEUPEPTIN TRIFLUOROACETATE SALT(147385-61-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 147385-61-3(Hazardous Substances Data)

Usage

Description

Leupeptin Trifluoroacetate Salt, also known as Leupeptin, is a potent protease inhibitor derived from the actinomycete Amycolatopsis mediterranei. It exhibits a strong astringent taste and possesses weak acidic properties. Its structure allows it to interact with biopolymers and macromolecules, making it a valuable compound for various applications in the pharmaceutical and research industries.

Uses

Used in Pharmaceutical and Research Applications:
Leupeptin Trifluoroacetate Salt is used as a protease inhibitor for the characterization of macroautophagic flux in vivo using leupeptin-based assays. This application is particularly important in the study of cellular processes and the development of therapeutic strategies for various diseases.
In addition to its use in macroautophagic flux assays, Leupeptin Trifluoroacetate Salt may also have potential applications in other areas of research and drug development, such as:
1. Used in Biochemical Research:
Leupeptin Trifluoroacetate Salt is used as a research tool for studying the role of proteases in various biological processes, including cell signaling, apoptosis, and inflammation.
2. Used in Drug Development:
Leupeptin Trifluoroacetate Salt may be employed in the development of novel therapeutic agents targeting protease-mediated diseases, such as cancer, neurodegenerative disorders, and autoimmune conditions.
3. Used in Diagnostic Applications:
Leupeptin Trifluoroacetate Salt can be utilized in the development of diagnostic tools and assays for the detection and monitoring of protease activity in various diseases.
4. Used in Drug Delivery Systems:
Leupeptin Trifluoroacetate Salt may be incorporated into drug delivery systems to improve the stability, bioavailability, and targeted delivery of protease inhibitors to specific tissues or cells.

InChI:InChI=1/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1