14742-36-0

Basic information

• Product Name: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID
• Synonyms: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID;3,4,5,6-TETRAFLUOROSALICYLIC ACID;2,3,4,5-Tetrafluoro-6-hydroxybenzoic acid
• CAS NO: 14742-36-0
• Molecular Formula: C₇H₂F₄O₃
• Molecular Weight: 210.08
• Mol File: 14742-36-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 173 °C
• Boiling Point: 282.1 °C at 760 mmHg
• Flash Point: 124.4 °C
• Appearance: /
• Density: 1.792 g/cm³
• Vapor Pressure: 0.00162mmHg at 25°C
• Refractive Index: 1.509
• PKA: 1.53±0.28(Predicted)
• CAS DataBase Reference: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(14742-36-0)
• EPA Substance Registry System: 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID(14742-36-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 36/37/39
• Hazardous Substances Data: 14742-36-0(Hazardous Substances Data)

Usage

General Description

3,4,5,6-Tetrafluoro-2-hydroxybenzoic acid, also known as TFHBA, is a carboxylic acid compound with the molecular formula C7H3F4O3. It is a white crystalline solid that is soluble in water and organic solvents. TFHBA is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of electronic materials. It is also utilized as a building block for the development of fluorescent sensors and dyes. TFHBA is a highly reactive compound that is primarily handled by trained professionals in controlled laboratory environments to ensure safety and proper handling.

InChI:InChI=1/C7H2F4O3/c8-2-1(7(13)14)6(12)5(11)4(10)3(2)9/h12H,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 3467-85-4 2,3,4,5-tetrafluorophenol 
• 38512-77-5 2,3,4,5-tetrafluoro-6-methoxybenzoic acid 
• 109-88-6 magnesium methanolate 
• 602-94-8 Pentafluorobenzoic acid 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 4487-61-0 5,6,7,8-tetrafluoro-2-methyl-4-oxo-4H-benzopyran-3-carboxylic acid ethyl ester 

Downstream Products

• 15068-09-4 ethyl 2-hydroxy-3,4,5,6-tetrafluorobenzoate 
• 22105-26-6 2-acetyloxy-3,4,5,6-tetrafluorobenzoic acid 

Relevant articles and documents

Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation

We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.