147539-20-6 Usage
Chemical class
Piperazine compounds This compound belongs to a class of organic compounds that contain a piperazine ring.
Piperazine ring
A six-membered nitrogen-containing ring The core structure of this compound is a piperazine ring, which is a six-membered ring with two nitrogen atoms.
Pyridyl group
A six-membered aromatic ring with one nitrogen atom This compound contains a pyridyl group, which is an aromatic ring similar to benzene but with one nitrogen atom replacing a carbon atom.
Propylamino substituent
An amino group attached to a propyl chain The compound has a propylamino group, which is an amino group (-NH2) attached to a three-carbon propyl chain (-CH2CH2CH3).
Dimethylethoxy carbonyl group
A protective group used in organic synthesis This group is a carbonyl (C=O) functional group with two methyl groups (-CH3) and an ethoxy group (-OCH2CH3) attached to it.
Potential pharmaceutical applications
Structural features and interactions with biological targets Due to its unique structure and potential to interact with biological targets, this compound may have applications in the development of new pharmaceuticals.
Further research and development
Interesting candidate for exploration The compound's properties and potential applications make it a promising candidate for further research and development in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 147539-20-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,5,3 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 147539-20:
(8*1)+(7*4)+(6*7)+(5*5)+(4*3)+(3*9)+(2*2)+(1*0)=146
146 % 10 = 6
So 147539-20-6 is a valid CAS Registry Number.
147539-20-6Relevant articles and documents
Substituted indoles as anti-AIDS pharmaceuticals
-
, (2008/06/13)
Substituted indoles of formula (I) STR1 are useful anti-AIDS pharmaceuticals.
Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors
Romero,Morge,Biles,Berrios-Pena,May,Palmer,Johnson,Smith,Busso,Tan,Voorman,Reusser,Althaus,Downey,So,Resnick,Tarpley,Aristoff
, p. 999 - 1014 (2007/10/02)
A variety of analogues of 1-[4-methoxy-3,5-dimethylbenzyl]-4-[3- (ethylamino)-2-pyridyl]piperazine hydrochloride (U-80493E) were synthesized and evaluated for their inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Replacement of the substituted aryl moiety with various substituted indoles provided bis(heteroaryl)piperazines (BHAPs) that were 10-100-fold more potent than U-80493E. The pyridyl portion of the lead molecule was found to be very sensitive to modifications. Extensive preclinical evaluations of several of these compounds led to the selection of 1-[(5-methoxyindol-2-yl)carbonyl]-4-[3-(ethylamino)-2- pyridyl]piperazine methanesulfonate (U-87201E, atevirdine mesylate) for clinical evaluation.
