147624-13-3 Usage
Description
3-Fluoro-2-methylbenzaldehyde is an aryl fluorinated building block, which is a type of organic compound that is characterized by the presence of a fluorine atom attached to an aromatic ring. 3-Fluoro-2-methylbenzaldehyde is known for its potential applications in various chemical and pharmaceutical processes due to its unique structure and properties.
Uses
Used in Pharmaceutical Industry:
3-Fluoro-2-methylbenzaldehyde is used as a reagent in the synthesis of resveratrol derivatives with curcumin moiety. These derivatives serve as antitubulin agents and have potential as antitumor agents, making them valuable in the development of cancer treatments.
Used in Enzyme Inhibition:
3-Fluoro-2-methylbenzaldehyde is also used in the preparation of indenopyrazine dicarbonitriles, which are inhibitors of deubiquitinating enzymes. These enzymes play a crucial role in various cellular processes, and their inhibition can have therapeutic implications in the treatment of certain diseases.
Used in Chemical Synthesis:
In addition to its applications in the pharmaceutical industry, 3-Fluoro-2-methylbenzaldehyde may also be used in chemical synthesis for the creation of various compounds and materials. Its unique structure and properties make it a versatile building block for a wide range of applications.
Check Digit Verification of cas no
The CAS Registry Mumber 147624-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,6,2 and 4 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 147624-13:
(8*1)+(7*4)+(6*7)+(5*6)+(4*2)+(3*4)+(2*1)+(1*3)=133
133 % 10 = 3
So 147624-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FO/c1-6-7(5-10)3-2-4-8(6)9/h2-5H,1H3
147624-13-3Relevant articles and documents
Directed Metalation of Aromatic Aldimines with Lithium 2,2,6,6-Tetramethylpiperidide
Flippin, Lee A.,Muchowski, Joseph M.,Carter, David S.
, p. 2463 - 2467 (2007/10/02)
N-Cyclohexyl aromatic aldimines are ortho-lithiated or o-methyl-lithiated with 2 equiv of lithium 2,2,6,6-tetramethylpiperidide (LTMP) in THF solution at -15 deg C.The lithiated intermediates generally reacted with alkyl halides or CO2 to provide ortho-functionalized aldimine products which could be readily converted to the corresponding aldehydes by hydrolysis with aqueous 4 M HCl.Aromatic aldimines derived from (+/-)-trans-2-methylcyclohexylamine or 3-amino-2,4-dimethylpentane are resistant toward C=N addition with 1 equiv of n-BuLi at 0 deg C in THF solution; however, they are also surprisingly resistant toward directed metalation reactions with either LTMP or n-BuLi.Exceptions to the ortho-directing and o-methyl-directing effects of the aldimine group were observed in a reaction of 3-methylthiophene-2-carboxaldehyde cyclohexylimine (7) with LTMP, followed by CH3I, which gave a 9:1 mixture of 3,5-dimethylthiophene-2-carboxaldehyde cyclohexylimine (22) and 5-ethyl-3-methylthiophene-2-carboxaldehyde cyclohexylimine (23), and a reaction of p-tolualdehyde 2,4-dimethylpent-3-ylimine (11) with either n-BuLi or LTMP, followed by CH3I, which gave p-ethylbenzaldehyde 2,4-dimethylpent-3-ylimine (25).
