147637-15-8

Basic information

• Product Name: 3-hydroxy-4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• Synonyms: 3-hydroxy-4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• CAS NO: 147637-15-8
• Molecular Weight: 255.273
• Mol File: 147637-15-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(147637-15-8)
• EPA Substance Registry System: 3-hydroxy-4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one(147637-15-8)

Safety Data

• Hazardous Substances Data: 147637-15-8(Hazardous Substances Data)

Upstream product

• 6833-23-4 3-methoxy-N-phenylbenzamide 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 4792-33-0 4-methoxyphthalide 
• 294629-59-7 methyl 4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-on-3-acetate 
• 294629-65-5 4-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-on-3-acetic acid 
• 147637-24-9 1,3-dihydro-4-methoxy-1-(2-methoxyphenyl)-1-isobenzofuranol 
• 1027188-22-2 1-(2,4-Dimethoxy-6-methoxymethyl-phenyl)-4-methoxy-1,3-dihydro-isobenzofuran-1-ol 

Relevant articles and documents

The behavior of 2-substituted-3-hydroxyisoindolinones in the reaction with sec-butyllithium

This paper presents a dualistic behavior of 2-substituted-3- hydroxyisoindolones in reactions with sec-butyllithium (sec-BuLi). 2-tert-Butyl-3-hydroxy-2,3-dihydro-1H-isoindol-1-one (1a) treated with sec-BuLi undergoes metalation at position 7. On the other hand, the reaction between 3-hydroxy-2-phenyl-2,3-dihydroxyisoindol-1-one (1j) and sec-BuLi results in 3-sec-butyl-2-phenyl-2,3-dihydroisiondol-1-one (3j).

Application of organolithium and related reagents in synthesis. Part 21. Synthetic strategies based on orthro-aromatic metallation. A concise regiospecific synthesis of arylnaphthalanes as precursors of naphthylisoquinoline alkaloids

A novel procedure is described for synthesising regioselectively substituted biaryls such as 12. It involves converting phthalides 4, via cycloaddition of dimethyl acetylenedicarboxylate to 1-arylisobenzofurans 6, into dimethyl 1-arylnaphthalene-2,3-dicar