147907-34-4

Basic information

• Product Name: (4-methylphenoxy) ((1S)-(1-methoxycarbonylethyl)amino)phosphinyl chloride
• Synonyms: (4-methylphenoxy) ((1S)-(1-methoxycarbonylethyl)amino)phosphinyl chloride
• CAS NO: 147907-34-4
• Molecular Weight: 291.671
• Mol File: 147907-34-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (4-methylphenoxy) ((1S)-(1-methoxycarbonylethyl)amino)phosphinyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methylphenoxy) ((1S)-(1-methoxycarbonylethyl)amino)phosphinyl chloride(147907-34-4)
• EPA Substance Registry System: (4-methylphenoxy) ((1S)-(1-methoxycarbonylethyl)amino)phosphinyl chloride(147907-34-4)

Safety Data

• Hazardous Substances Data: 147907-34-4(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 878-17-1 4-methylphenyl phosphorodichloridate 

Downstream Products

• 1239369-14-2 C₂₀H₂₃IN₃O₈P 

Relevant articles and documents

Prodrug compound and application ofprodrug compound in treatment of cancer

The present invention provides a compound indicated by a formula (I), pharmaceutically acceptable salts or esters thereof, a pharmaceutical composition of the compound, and application of the compoundand the pharmaceutical composition in the inhibition or regulation of the activity of tyrosine kinase and treating disease symptoms or symptoms including cancer mediated by tyrosine kinase.

Phosphoramidate and phosphate prodrugs of (-)-β-D-(2R,4R)-dioxolane- thymine: Synthesis, anti-HIV activity and stability studies

A series of phosphoramidate and phosphate prodrugs of DOT were synthesized via dichlorophosphate or H-phosphonate chemistry and evaluated for their anti-HIV activity against LAI M184V mutants in PBM cells as well as for their cytotoxicity. The antiviral and cytotoxic profiles of the prodrugs were compared with that of the parent compound (DOT), and it was found that four aryl phosphoramidates 5, 18, 20, and 26 showed a significant enhancement (8- to 12-fold) in anti-HIV activity without cytotoxicity. Chemical stability of these prodrugs was evaluated in phosphate buffer at pH values of biological relevance (i.e., pH 2.0 and 7.4). Enzymatic hydrolysis was also studied in esterase or lipase in buffer solution. Chemical stability studies indicate that the phosphoramidates have good chemical stability at pH 2.0 and at pH 7.4 phosphate buffer. Phosphoramidate prodrugs were hydrolyzed in vitro by esterase or lipase and found to be better substrates for lipases than for esterases. 1,3-Diol cyclic phosphates showed potent anti-HIV activity without increasing the cytotoxicity compared with that of DOT and have good chemical and enzymatic stability. Long-chain lipid phosphates, although showed potent anti-HIV activity, exhibited increased cytotoxicity.