148-51-6 Usage
Description
4-Deoxypyridoxine hydrochloride, also known as 4-deoxy Pyridoxine (DOP), is a vitamin B6 antimetabolite with a wide range of biological activities. It is a solid compound that inhibits the transport of pyridoxine, pyridoxal, and pyridoxamine, and has been shown to reduce the growth of certain cells. DOP exhibits various effects on cellular functions and structures, making it a compound of interest in the fields of medicine and biology.
Uses
Used in Pharmaceutical Applications:
4-Deoxypyridoxine hydrochloride is used as a pharmaceutical agent for inducing a vitamin B6 deficient status, which can alter the function and ultrastructure of endothelial cells (EC) in a manner similar to vascular disease. This property makes it a valuable tool for studying the effects of vitamin B6 deficiency on cellular processes and vascular health.
Used in Research Applications:
In research, 4-Deoxypyridoxine hydrochloride is used as a tool to study the effects of vitamin B6 deficiency on various cellular processes. It is particularly useful in investigating the role of vitamin B6 in the growth of S. carlsbergensis cells, as well as its impact on the activity of lysyl oxidase, which is involved in collagen and elastin crosslinking.
Used in Neurological Applications:
4-Deoxypyridoxine hydrochloride is used as a compound to study its effects on neurological conditions. It has been shown to decrease latency to first seizure in mice and increase the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. This makes it a valuable tool for understanding the role of vitamin B6 in neurological function and the potential development of treatments for seizure disorders.
Used in Immunological Applications:
In the field of immunology, 4-Deoxypyridoxine hydrochloride is used to study its effects on the immune system. It has been shown to reduce the production of TNF-α and IL-6 in mice infected with T. spiralis, suggesting that it may play a role in modulating immune responses. This application could be useful in the development of therapies for autoimmune diseases and other conditions involving immune system dysregulation.
Used in Material Science Applications:
As a solid compound, 4-Deoxypyridoxine hydrochloride may also have potential applications in material science, particularly in the development of new materials with unique properties. Its chemical properties and interactions with other compounds could be harnessed to create novel materials with specific applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 148-51-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 148-51:
(5*1)+(4*4)+(3*8)+(2*5)+(1*1)=56
56 % 10 = 6
So 148-51-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11NO2.ClH/c1-5-7(4-10)3-9-6(2)8(5)11;/h3,10-11H,4H2,1-2H3;1H
148-51-6Relevant articles and documents
Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol
Chaudhary, Chhabi Lal,Chaudhary, Prakash,Dahal, Sadan,Bae, Dawon,Nam, Tae-gyu,Kim, Jung-Ae,Jeong, Byeong-Seon
, (2020/08/05)
6-Aminopyridin-3-ol scaffold has shown an excellent anti-inflammatory bowel disease activity. Various analogues with the scaffold were synthesized in pursuit of the diversity of side chains tethering on the C(6)-position. Structure-activity relationship among the analogues was investigated to understand the effects of the side chains and their linkers on their anti-inflammatory activities. In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself. It expedited us to synthesize diverse ring-modified analogues of a representative pyridine-3-ol, 6-acetamido-2,4,5-trimethylpyridin-3-ol (9). In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds 9, 17, and 19 were greater than tofacitinib, an orally available anti-colitis drug, and compound 17 showed the greatest activity. In addition, TNF-α-induced angiogenesis, which permits more inflammatory cell migration into inflamed tissues, was significantly blocked by compounds 17 and 19 in a concentration-dependent manner. In the comparison of in vivo therapeutic effects of compounds 9, 17, and 19 on dextran sulfate sodium (DSS)-induced colitis in mice, compound 17 was the most potent and efficacious, and compound 19 was better than compound 9 which showed a similar degree of inhibitory effect to tofacitinib. Taken together, it seems that either the trimethyl system or the hydroxyl group on the pyridinol ring is essential to the activity. This finding might become a new milestone in the development of pyridinol-based anti-inflammatory bowel disease agents.
Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine
Shtyrlin,Vafina,Pugachev,Khaziev,Nikitina,Zeldi,Iksanova,Shtyrlin, Yu. G.
, p. 537 - 545 (2017/03/08)
Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro.
INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
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Paragraph 0118, (2016/03/09)
Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
