148-56-1 Usage
Originator
Ademol,Squibb,US,1959
Manufacturing Process
Chilled 3-trifluoromethylaniline (32.2 g) is added dropwise over a 45-minute
period to 150 ml of chlorosulfonic acid with stirring and cooling. The ice bath
is removed and 140 g of sodium chloride is added over 3 hours. The mixture
is heated on a water bath for 30 minutes, then gradually up to 160°C over 6
hours. The cooled reaction mixture is diluted with 500 ml of an ice water
slurry and taken into ether. The ether is dried and evaporated to leave 5-
trifluoromethylamine-2,4-disulfonyl chloride.The crude residue is heated on the steam bath for 1 hour with 75 ml of
concentrated ammonium hydroxide. Cooling and filtration gives 2,4-
disulfamyl-5-trifluoromethylaniline, MP 241°C to 243°C.This intermediate is treated with an excess of 98% formic acid at steam bath
temperature for 3 hours. Evaporation and dilution with water gives 7-sulfamyl-
6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide, MP 304°C to 308°C.
Therapeutic Function
Carbonic anhydrase inhibitor
Check Digit Verification of cas no
The CAS Registry Mumber 148-56-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 148-56:
(5*1)+(4*4)+(3*8)+(2*5)+(1*6)=61
61 % 10 = 1
So 148-56-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-3H,(H2,12,15,16)(H,13,14,17,18)
