148120-34-7

Basic information

• Product Name: 2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindole
• Synonyms: 2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindole
• CAS NO: 148120-34-7
• Molecular Weight: 239.317
• Mol File: 148120-34-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindole(148120-34-7)
• EPA Substance Registry System: 2-(4-methoxybenzyl)-2,3-dihydro-1H-isoindole(148120-34-7)

Safety Data

• Hazardous Substances Data: 148120-34-7(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 91-13-4 α,α'-dibromo-o-xylene 
• 89-92-9 2-methylbenzyl bromide 

Downstream Products

• 104-21-2 p-methoxybenzyl acetate 

Relevant articles and documents

An efficient method for the synthesis of 2, 3-dihydro-lH-isoindoles

The synthesis of Af-substituted 2, 3-dihydro-lH-isoindoles from α, α'-dibromo-o-xylene and various primary amines in basic medium under ambient conditions is described. Especially the selection of 1, 4-dioxane as solvent and sodium hydroxide as suitable base to maintain the homogeneity of the medium are key steps to promote the reaction efficiently. Primary alkyl amines react faster as compared to their aromatic analogues under the conditions studied. Irrespective of the starting amine used, all the reactions proceed smoothly and provide 2, 3-dihydro-lH-isoindoles derivatives in excellent yields compared to hitherto known methods.