14814-99-4

Basic information

• Product Name: 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide
• Synonyms: 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide
• CAS NO: 14814-99-4
• Molecular Weight: 253.172
• Mol File: 14814-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide(14814-99-4)
• EPA Substance Registry System: 2,2,3,3,3-pentafluoro-N-(o-tolyl)propanamide(14814-99-4)

Safety Data

• Hazardous Substances Data: 14814-99-4(Hazardous Substances Data)

Upstream product

• 611-23-4 2-nitrosotoluene 
• 356-42-3 2,2,3,3,3-pentafluoropropanoic anhydride 
• 95-53-4 o-toluidine 

Relevant articles and documents

Synthesis of Fluorinated Amide Derivatives via a Radical N-Perfluoroalkylation-Defluorination Pathway

A one-pot approach to fluorinated hydroxamic acid, amide, and thioamide derivatives is reported. The reaction proceeds via an N-perfluoroalkylation of nitrosoarenes with perfluoroalkanesulfinates, resulting in labile N-perfluoroalkylated hydroxylamines. By the addition of suitable additives, a controllable oxy/thiodefluorination of the fluorinated hydroxylamine intermediates was achieved. The method highlights N-perfluoroalkylated amines as versatile intermediates for further synthesis.