148345-05-5

Basic information

• Product Name: (Z)-3-(3,4,5-trimethoxyphenylmethylidene)isobenzofuran-1(3H)-one
• Synonyms: (Z)-3-(3,4,5-trimethoxyphenylmethylidene)isobenzofuran-1(3H)-one
• CAS NO: 148345-05-5
• Molecular Weight: 312.322
• Mol File: 148345-05-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (Z)-3-(3,4,5-trimethoxyphenylmethylidene)isobenzofuran-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(3,4,5-trimethoxyphenylmethylidene)isobenzofuran-1(3H)-one(148345-05-5)
• EPA Substance Registry System: (Z)-3-(3,4,5-trimethoxyphenylmethylidene)isobenzofuran-1(3H)-one(148345-05-5)

Safety Data

• Hazardous Substances Data: 148345-05-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 951-82-6 3,4,5-trimethoxyphenyl acetic acid 
• 88-67-5 2-Iodobenzoic acid 
• 53560-33-1 3,4,5-trimethoxyphenylacetylene 
• 61260-15-9 dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate 

Downstream Products

• 365222-04-4 4-(3,4,5-trimethoxy-benzyl)-2H-phthalazin-1-one 

Relevant articles and documents

Synthesis, bioevaluation and structural study of substituted phthalazin-1(2H)-ones acting as antifungal agents

Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2- methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A physicochemical study performed on compound 5 revealed its conformational and electronic characteristics, providing us with useful data for the future design of novel related antifungal analogues.

Copper-catalyzed preparation of γ-alkylidenebutenolides and isocoumarins under mild palladium-free conditions

A general and efficient copper(I)-catalyzed cross-coupling and heterocyclization reaction of terminal alkynes and β-iodo-α,β- unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5-ylidenebutenolides and 3-substituted isocoumarins with excellent regio- and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.

Vasorelaxant activity of phthalazinones and related compounds

Several series of dihydrostilbenamide, imidazo[2,1-a]isoindole, pyrimido[2,1-a]isoindole and phthalazinone derivatives were obtained and their vasorelaxant activity was measured on isolated rat aorta rings pre-contracted with phenylephrine (10-5 M). Some phthalazinones attained, practically, the total relaxation of the organ at micromolar concentrations. For the most potent compound 9h (EC50 = 0.43 μM) the affinities for α1A, α1B and α1D adrenergic sub-receptors were determined.