148564-90-3

Basic information

• Product Name: 2,2,2-trifluoro-N-(2-(3-hydroxy-3-phenylprop-1-ynyl)phenyl)acetamide
• Synonyms: 2,2,2-trifluoro-N-(2-(3-hydroxy-3-phenylprop-1-ynyl)phenyl)acetamide
• CAS NO: 148564-90-3
• Molecular Weight: 319.283
• Mol File: 148564-90-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-(2-(3-hydroxy-3-phenylprop-1-ynyl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(2-(3-hydroxy-3-phenylprop-1-ynyl)phenyl)acetamide(148564-90-3)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(2-(3-hydroxy-3-phenylprop-1-ynyl)phenyl)acetamide(148564-90-3)

Safety Data

• Hazardous Substances Data: 148564-90-3(Hazardous Substances Data)

Upstream product

• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 407-25-0 trifluoroacetic anhydride 
• 197729-98-9 α-[2-(2-aminophenyl)ethynyl]benzenemethanol 

Downstream Products

• 1513872-17-7 2-((4-(4-fluorophenyl)piperazin-1-yl)(phenyl)methyl)-1H-indole 
• 1196834-80-6 N-((1H-indol-2-yl)(phenyl)methyl)butan-1-amine 
• 1196834-78-2 2-[(4-ethylpiperazin-1-yl)(phenyl)methyl]-1H-indole 
• 612-96-4 2-Phenylquinoline 
• 1022-86-2 2-benzoylindole 
• 155694-57-8 [E]-3-phenyl-1-(2-trifluoroacetamidophenyl)prop-2-en-1-one 
• 78396-00-6 2-aminochalcone 
• 16619-14-0 2-phenyl-2,3-dihydro-1H-quinolin-4-one 
• 135675-09-1 ethyl (E)-3-styryl-1H-indole-2-carboxylate 

Relevant articles and documents

2-Alkylindoles via palladium-catalyzed reductive cyclization of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates

The reaction of ethyl 3-(o-trifluoroacetamidophenyl)-1-propargyl carbonates with formate anions in the presence of Pd(PPh3)4 affords 2-alkylindoles in good to excellent yields.

Sequential alkylation/cyclization/isomerization of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters: A new route to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles

The reaction of ethyl 3-(o-trifluoroacetamidoaryl)-1-propargylic esters with ethyl iodoacetate or α-bromoacetophenone in the presence of K 2CO3 in DMSO provides a new simple access to 2-acyl- and 2-ethoxycarbonyl-3-alkenyl indoles.

Palladium-catalyzed heteroannulation with acetylenic carbinols as synthons-synthesis of quinolines and 2,3-dihydro-4(1H)-quinolones

o-Iodoanilides 4 reacted with terminal acetylenic carbinols 5 under palladium-catalyzed conditions to yield o-substituted anilides 6. Most of the anilides 6 could be cyclized with NaOEt/EtOH to 2-arylquinolines 2. o-Iodoanilines 7 reacted with carbinols 5 leading to 8 which on palladium(II) assisted cyclisation afforded substituted quinolines 2. An excellent synthesis of the alkaloid dubamine (2n) is reported. Also, the anilides 6 on acid-catalyzed rearrangement, deprotection and cyclisation led to the 2-aryl-2, 3-dihydro-4(1H)-quinolones 16.