148616-42-6

Basic information

• Product Name: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane
• Synonyms: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane
• CAS NO: 148616-42-6
• Molecular Weight: 260.657
• Mol File: 148616-42-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane(148616-42-6)
• EPA Substance Registry System: (-)-(R)-2-chloro-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane(148616-42-6)

Safety Data

• Hazardous Substances Data: 148616-42-6(Hazardous Substances Data)

Upstream product

• 161853-73-2 (2S,4R)-5,5-Dimethyl-4-phenyl-[1,3,2]dioxaphosphinane 2-oxide 
• 52178-66-2 (S)-(+)-1-phenyl-2,2-dimethyl-1,3-propanediol 
• 98674-80-7 (R)-(-)-5,5-dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 
• 33950-46-8 1-phenyl-2,2-dimethyl-1,3-propanediol 
• 98675-02-6 2-chloro-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide 

Downstream Products

• 344913-70-8 2-(R)-[18O]hydroxy-2-oxo-5,5-dimethyl-4-(R)-phenyl-1,3,2-dioxaphosphorinane 

Relevant articles and documents

Formation of diphosphates. A NMR study on the mechanism and stereochemistry of diphosphate formation from chiral dioxaphosphorinanes

During the use of chiral 2-oxo-1,3,2-dioxaphosphorinanes as derivatizing reagents in the enantiomeric excess determination of amines, alcohols, and unprotected amino acids, minor traces of side reaction products were observed by 1H and 31

(S)-2H-2-oxo-5,5-dimethyl-4(R)-phenyl-1,3,2-dioxaphosphorinane, a New Reagent for the Enantiomeric Excess Determination of Unprotected Amino Acids using 31P NMR

Diastereomeric amide derivatives of title phosphorinane 2 and unprotected amino acids are easily prepared in aqueous solutions, showing well separated signals in the 31P NMR spectra allowing accurate e.e. determination.