148625-77-8

Basic information

• Product Name: FMOC-PRO-OL
• Synonyms: (S)-1-FMOC-2-PYRROLIDINEMETHANOL;(S)-N-FMOC-2-PYRROLIDINEMETHANOL;N-(9-FLUORENYLMETHOXYCARBONYL)-L-PROLINOL;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-PROLINOL;N-ALPHA-FMOC-L-PROLINOL;N-FMOC-L-PROLINOL;FMOC-L-PROLINOL;FMOC-L-PRO-OL
• CAS NO: 148625-77-8
• Molecular Formula: C₂₀H₂₁NO₃
• Molecular Weight: 323.39
• Product Categories: Amino Acids
• Mol File: 148625-77-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 90℃
• Boiling Point: 504.638 °C at 760 mmHg
• Flash Point: 258.996 °C
• Appearance: /
• Density: 1.242 g/cm³
• Vapor Pressure: 5.26E-11mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: −20°C
• PKA: 14.77±0.10(Predicted)
• BRN: 8789847
• CAS DataBase Reference: FMOC-PRO-OL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-PRO-OL(148625-77-8)
• EPA Substance Registry System: FMOC-PRO-OL(148625-77-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 148625-77-8(Hazardous Substances Data)

Usage

Description

FMOC-PRO-OL, also known as Fmoc-l-prolinol, is a chemical compound that serves as a valuable intermediate for organic synthesis. It is characterized by its white or off-white powder appearance.

Uses

Used in Organic Synthesis:
FMOC-PRO-OL is used as a synthetic intermediate for the development of various organic compounds. Its application in organic synthesis is due to its ability to facilitate the formation of complex molecular structures, which can be utilized in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
Within the pharmaceutical industry, FMOC-PRO-OL is used as a building block for the synthesis of peptides and other bioactive molecules. Its role in this industry is to provide a versatile and efficient means of constructing peptide-based drugs, which can be employed for the treatment of various diseases and medical conditions.
Used in Research and Development:
FMOC-PRO-OL is also utilized in research and development settings, where it serves as a key component in the design and synthesis of novel compounds with potential applications in various fields, including medicine, agriculture, and materials science. Its use in R&D is driven by the need for innovative and effective solutions to address contemporary challenges in these areas.

InChI:InChI=1/C20H21NO3/c22-12-14-6-5-11-21(14)20(23)24-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-4,7-10,14,19,22H,5-6,11-13H2/t14-/m0/s1

Upstream product

• 71989-31-6 Fmoc-Pro-OH 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 329309-00-4 Fmoc-Pro-N₃ 
• 186202-18-6 (S)-(-)-2,2,2-trifluoro-1-(2-(hydroxymethyl)pyrrolidin-1-yl)ethanone 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 929120-62-7 (R,E)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-((4-methoxyphenyl)dimethylsilyl)hex-4-en-1-one 
• 886990-77-8 C₂₉H₅₀N₂O₃SSi 
• 886990-66-5 C₃₉H₅₂N₂O₅SSi 
• 391624-45-6 2-[(4-nitro-phenoxycarbonylamino)-methyl]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

O-Alkyl S-(Pyridin-2-yl)carbonothiolates: Operationally Simple and Highly Nitrogen-Selective Reagents for Alkoxy Carbonylation of Amino Groups

Amino groups are selectively protected in good yields by reaction with O-Alkyl S-(pyridin-2-yl)carbonothiolates in an appropriate solvent at room temperature in air. Even glucosamine, which contains multiple hydroxyl groups, is selectively N-protected in methanol.

Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton

Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

MULTICYCLIC COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.