148637-74-5

Basic information

• Product Name: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)
• Synonyms: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI);2-CHLORO-1,3-THIAZOLE-5-CARBONYL CHLORIDE;2-Chloro-1,3-thiazole-5-carbonyl chloride 97%;2-Chlorothiazole-5-carbonylchloride
• CAS NO: 148637-74-5
• Molecular Formula: C₄HCl₂NOS
• Molecular Weight: 182.02784
• Product Categories: ACIDHALIDE
• Mol File: 148637-74-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 280.1°C at 760 mmHg
• Flash Point: 123.2°C
• Appearance: /
• Density: 1.647g/cm³
• Vapor Pressure: 0.00386mmHg at 25°C
• Refractive Index: 1.601
• PKA: -1.67±0.10(Predicted)
• CAS DataBase Reference: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)(148637-74-5)
• EPA Substance Registry System: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)(148637-74-5)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 148637-74-5(Hazardous Substances Data)

Usage

General Description

5-Thiazolecarbonyl chloride, 2-chloro- (9CI) is a chemical compound that belongs to the thiazolecarbonyl chloride family. It is a colorless or light yellow clear liquid with a pungent odor. 5-Thiazolecarbonyl chloride, 2-chloro- (9CI) is primarily used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is a versatile intermediate that can be used in the synthesis of various thiazole-containing compounds, which have applications in the fields of medicine and agriculture. Additionally, it can also be used as an intermediate in the production of dyes and pigments. However, it is important to handle this compound with caution as it is corrosive and can cause irritation to the skin, eyes, and respiratory system upon contact.

InChI:InChI=1/C4HCl2NOS/c5-3(8)2-1-7-4(6)9-2/h1H

Upstream product

• 54045-76-0 2-bromo-thiazole-5-carboxylic acid 
• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 

Downstream Products

• 81449-93-6 ethyl 2-chloro-thiazole-5-carboxylate 
• 302964-11-0 2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 

Relevant articles and documents

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Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N′-arylpiperazine series

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