148642-42-6

Basic information

• Product Name: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride
• Synonyms: GR 127935 hydrate hydrochloride;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride;N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrochloride hydrate
• CAS NO: 148642-42-6
• Molecular Formula: C29H31N5O3HCl
• Molecular Weight: 0
• Mol File: 148642-42-6.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble10mg/mL, clear
• CAS DataBase Reference: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride(148642-42-6)
• EPA Substance Registry System: N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride(148642-42-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 148642-42-6(Hazardous Substances Data)

Usage

Description

N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride is a complex organic compound with a chemical structure that includes a biphenyl core, a piperazine ring, and an oxadiazol group. It is a hydrate form of the compound, which means it contains water molecules as part of its structure. The hydrochloride salt form indicates that it has been treated with hydrochloric acid, which can improve its solubility and stability.

Uses

Used in Pharmaceutical Industry:
N-[4-Methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-carboxamide hydrate hydrochloride is used as a selective and potent 5-HT1B/1D serotonin receptor antagonist for the development of medications targeting various central nervous system disorders. Its high selectivity for the 5-HT1B and 5-HT1D receptors allows for targeted treatment with potentially fewer side effects compared to non-selective antagonists.
Used in Research Applications:
In the field of neuroscience and pharmacology, this compound serves as a valuable research tool for studying the role of serotonin receptor subtypes 5-HT1B and 5-HT1D in various physiological and pathological processes. It can be used to investigate the mechanisms underlying the anti-inflammatory activity of certain drugs, such as sumatriptan, following myocardial ischemia-reperfusion injury and testicular torsion/detorsion.
Used in Drug Delivery Systems:
Similar to gallotannin, this compound may also benefit from the development of novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Organic and metallic nanoparticles could be employed as carriers for this compound, potentially improving its efficacy in treating the targeted conditions.

Biochem/physiol Actions

Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.