148701-78-4

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 3-oxo-2-phenyl-, 1,1-dimethylethyl ester
• CAS NO: 148701-78-4
• Molecular Formula: C16H21NO3
• Molecular Weight: 275.348
• Mol File: 148701-78-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 3-oxo-2-phenyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 3-oxo-2-phenyl-, 1,1-dimethylethyl ester(148701-78-4)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 3-oxo-2-phenyl-, 1,1-dimethylethyl ester(148701-78-4)

Safety Data

• Hazardous Substances Data: 148701-78-4(Hazardous Substances Data)

Usage

Common uses

Synthesis of pharmaceuticals, agrochemicals, and other fine chemicals; building block for the preparation of various compounds

Appearance

Colorless to slightly yellow liquid

Molecular weight

263.33

Safety precautions

May be harmful if ingested, inhaled, or in contact with skin; should be stored in a cool, dry, and well-ventilated area away from incompatible substances.

Upstream product

• 178918-29-1 furan-2-ylmethylcarbamic acid tert-butyl ester 
• 108-86-1 bromobenzene 
• 1179348-67-4 C₁₂H₂₃NO₄S 
• 79-37-8 oxalyl dichloride 
• 144-55-8 sodium hydrogencarbonate 
• 159249-47-5 tert-butyl (2S,3S)-3-hydroxy-2-phenylpiperidine-1-carboxylate 
• 138495-07-5 (E)-methyl 4-(benzylideneamino)butanoate 
• 100-52-7 benzaldehyde 
• 3308-02-9 3-hydroxy-2-phenylpyridine 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 479030-35-8 1-benzyl-2-phenylpiperidin-3-one 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 148700-84-9 cis-2-phenyl-3-[(3,5-bis(trifluoromethyl)benzyl)oxy]piperidine 

Relevant articles and documents

Synthesis of 2-Arylpiperidines via pd-catalyzed arylation of aza-Achmatowicz rearrangement products with arylboronic acids

The first Pd-catalyzed arylation of aza-Achmatowicz rearrangement products with arylboronic acids is achieved, providing versatile 2-Aryldihydropyridinones for facile synthesis of highly functionalized 2-Arylpiperidines. Key to this arylation is the use of non-phosphine-ligand palladium precatalyst. The substrate scope is demonstrated with >26 examples, and the utility of 2-Aryldihydropyridinones is illustrated by the synthesis of a small collection of 2-Arylpiperidines with substituents or functional groups at any carbon (C2-C6) as well as two NK1 receptor antagonists (+)-CP-999,94 and (+)-L-733,060.

Iridium-catalyzed selective hydrogenation of 3-hydroxypyridinium salts: A facile synthesis of piperidin-3-ones

The selective hydrogenation of 3-hydroxypyridinium salts has been achieved using a homogeneous iridium catalyst, providing a direct access to 2- and 4-substituted piperidin-3-one derivatives with high yields, which are important organic synthetic intermediates and the prevalent structural motifs in pharmaceutical agents. Mild reaction conditions, high chemoselectivity, and easy scalability make this reaction highly practical for the synthesis of piperidin-3-ones.

Use of NK-1 receptor antagonists for treating major depressive disorders

The present invention provides methods for the treatment of major depressive disorders comprising oral administration of an orally active, long acting, CNS-penetrant NK-1 receptor antagonist and pharmaceutical compositions comprising such a NK-1 receptor