148796-53-6

Basic information

• Product Name: ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
• Synonyms: HYDROXYFARNESYL PHOSPHATE;HFPA;(+/-)-1-HYDROXY-3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENE-1-PHOSPHONIC ACID;ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID;A-hydroxyfarnesylphosphonic acid;alpha-Hydroxyfarnesylphosphonic aicd;ALPHA-HYDROXYFARNESYL PHOSPHONIC ACID ETHANOL SOLUTION;MONZTFSZTWQCKH-IJFRVEDASA-N
• CAS NO: 148796-53-6
• Molecular Formula: C15H27O4P
• Molecular Weight: 302.35
• EINECS: 200-578-6
• Mol File: 148796-53-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID(148796-53-6)
• EPA Substance Registry System: ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID(148796-53-6)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36-7
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 148796-53-6(Hazardous Substances Data)

Usage

Description

ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, also known as α-hydroxy Farnesyl phosphonic acid, is a nonhydrolyzable analog of farnesyl pyrophosphate. It functions as a competitive inhibitor of farnesyl transferase (FTase), playing a significant role in the processing of Ras in Ha-ras-transformed NIH3T3 cells. ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID has the potential to be utilized in various applications due to its unique properties and ability to inhibit specific cellular processes.

Uses

Used in Pharmaceutical Industry:
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID is used as a therapeutic agent for targeting the Ras protein, which is frequently mutated in various types of cancer. By inhibiting the processing of Ras, this compound can potentially disrupt the signaling pathways that contribute to the development and progression of cancer.
Used in Cancer Research:
In the field of cancer research, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID serves as a valuable tool for studying the role of Ras proteins in tumorigenesis. Its ability to inhibit farnesyl transferase (FTase) allows researchers to investigate the underlying mechanisms of Ras-mediated cellular processes and identify potential therapeutic targets for cancer treatment.
Used in Drug Development:
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID is utilized as a lead compound in the development of novel drugs targeting the Ras protein and its associated signaling pathways. Its inhibitory properties make it a promising candidate for the creation of new therapeutic agents that can effectively combat cancer and other diseases associated with Ras mutations.
Used in Biochemical Studies:
In biochemical research, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID is employed as a specific inhibitor of farnesyl transferase (FTase) to study the enzyme's role in protein prenylation and its impact on cellular processes. ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID can help researchers understand the molecular mechanisms involved in protein modification and the consequences of inhibiting FTase activity on cell function.