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1489-97-0

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1489-97-0 Usage

Description

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is an organic compound with a unique cyclic structure that features a dioxaspiro core and a carboxylate group. It is a versatile intermediate in the synthesis of various pharmaceutical compounds due to its chemical reactivity and structural properties.

Uses

Used in Pharmaceutical Industry:
Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is used as a key intermediate for the synthesis of arylcyclohexanones, which are analgesics. These compounds are effective in providing pain relief and are used to treat various conditions that cause discomfort.
Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is also used as a precursor in the development of metalloproteinase inhibitors. These inhibitors play a crucial role in regulating the activity of metalloproteinases, which are enzymes involved in various physiological processes, including tissue remodeling and inflammation.
Furthermore, ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is utilized in the synthesis of benzimidazole derivatives, which serve as therapeutic TRPM8 receptor modulators. TRPM8 is a temperature-sensitive ion channel that can be targeted for the treatment of various conditions, such as chronic pain and cold hypersensitivity.
Lastly, ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is employed in the preparation of apoptosis-inducing agents. Apoptosis, or programmed cell death, is a vital process in maintaining cellular homeostasis. Modulating apoptosis can be beneficial in treating diseases where cell survival is disrupted, such as cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 1489-97-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,8 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1489-97:
(6*1)+(5*4)+(4*8)+(3*9)+(2*9)+(1*7)=110
110 % 10 = 0
So 1489-97-0 is a valid CAS Registry Number.

1489-97-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1489-97-0 SDS

1489-97-0Relevant articles and documents

Practical Manufacture of 4-Alkyl-4-aminocyclohexylalcohols Using Ketoreductases

García-Cerrada, Susana,Redondo-Gallego, Laura,Martínez-Olid, Francisco,Rincón, Juan A.,García-Losada, Pablo

, p. 779 - 784 (2017)

The diastereoselective preparation of cis- or trans-4-substituted-4-aminocyclohexyl alcohols by conventional chemical processes reported in the literature requires long synthetic sequences and is not amenable to scale-up. In the past decade, ketoreductases (KREDs) have emerged as a powerful approach for the preparation of chiral secondary alcohols from prochiral ketones. This paper describes the diastereoselective preparation at the kilo scale of cis-allyl N-(4-hydroxy-1-methyl-cyclohexyl)carbamate (6a) via ketoreductase transformation. The methodology was also applicable to a set of different analogous cyclic ketones.

Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination

Ces, Sabela Vega,Fernández-Ibá?ez, M. ángeles,Jia, Wen-Liang

supporting information, p. 6259 - 6277 (2021/05/29)

Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by late-stage C-H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.

Ytterbium-Catalyzed Intramolecular [3 + 2] Cycloaddition based on Furan Dearomatization to Construct Fused Triazoles

Xu, Xiaoming,Zhong, Ying,Xing, Qingzhao,Gao, Ziwei,Gou, Jing,Yu, Binxun

supporting information, p. 5176 - 5181 (2020/07/14)

The 1,2,3-triazole-containing polycyclic architecture widely exists in a broad spectrum of synthetic bioactive molecules, and the development of expeditious methods to synthesize these skeletons remains a challenging task. In this work, the catalytic cyclization of biomass-derived 2-furylcarbinols with an azide to form fused triazoles is described. This approach takes advantage of a single catalyst Yb(OTf)3 and operates via a furfuryl-cation-induced intramolecular [3 + 2] cycloaddition/furan ring-opening cascade.

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