1489389-18-5

Basic information

• Product Name: CCT245737
• Synonyms: CCT245737
• CAS NO: 1489389-18-5
• Molecular Formula: C16H16F3N7O
• Molecular Weight: 379.3397496
• EINECS: -0
• Mol File: 1489389-18-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 547.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• PKA: 8.56±0.40(Predicted)
• CAS DataBase Reference: CCT245737(CAS DataBase Reference)
• NIST Chemistry Reference: CCT245737(1489389-18-5)
• EPA Substance Registry System: CCT245737(1489389-18-5)

Safety Data

• Hazardous Substances Data: 1489389-18-5(Hazardous Substances Data)

Usage

Uses

CCT245737 is a CHK inhibitor.

Upstream product

• 135065-64-4 tert-butyl (2R)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate 
• 135065-71-3 (R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester 
• 113305-94-5 2-amino-5-cyanopyrazine 
• 505084-58-2 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid 
• 1061358-78-8 2-chloro-5-(trifluoromethyl)pyridin-4-amine 
• 503455-76-3 (R)-tert-butyl 2-(((methylsulfonyl)oxy)methyl)morpholine-4-carboxylate 
• 148638-76-0 tert-butyl (2S)-2-({[(4-methylphenyl)sulfonyl]oxy}methyl)morpholine-4-carboxylate 
• 135065-76-8 tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate 

Relevant articles and documents

METHODS FOR SYNTHESIS OF CHK1 INHIBITORS

The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.

5-[[4-[[MORPHOLIN-2-YL]METHYLAMINO]-5-(TRIFLUOROMETHYL)-2-PYRIDYL]AMINO]PYRAZINE-2-CARBONITRILE AND THERAPEUTIC USES THEREOF

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to 5-[[4-[[morpholin-2-yl]methylamino]-5- (trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile compounds (referred to her