149022-20-8

Basic information

• Product Name: ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT
• Synonyms: 5'-ADENYLIC ACID SODIUM SALT;5-ADENYLIC ACID, SODIUM SALT;5'-AMP 2NA;5'-AMP DISODIUM SALT;5'-AMP-NA2;5'-AMP SODIUM SALT;AMP, 2NA;AMP DISODIUM SALT
• CAS NO: 149022-20-8
• Molecular Formula: C10H12N5Na2O7P
• Molecular Weight: 391.18
• EINECS: 224-961-2
• Product Categories: API intermediates;nucleoside
• Mol File: 149022-20-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 798.5oC at 760mmHg
• Flash Point: 436.7oC
• Appearance: White/crystalline
• Storage Temp.: −20°C
• Solubility: H2O: soluble
• CAS DataBase Reference: ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT(149022-20-8)
• EPA Substance Registry System: ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT(149022-20-8)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: AU7481600
• F: 1-10
• Hazardous Substances Data: 149022-20-8(Hazardous Substances Data)

Usage

Description

ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT, also known as Adenosine 5′-monophosphate sodium salt, is an organic compound that plays a crucial role in various biological processes. It is a nucleotide consisting of adenine, a five-carbon sugar, and a phosphate group, which is essential for the proper functioning of cells. Adenosine 5′-monophosphate sodium salt is involved in cellular energy transfer, signal transduction, and the synthesis of nucleic acids.

Uses

Used in Reactivation Medium:
ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT is used as a component of reactivation medium for reanimating mouse sperm extracted from caudae epididymides. This application is crucial for sperm motility studies, as it helps in understanding the factors that influence sperm movement and fertility.
Used in Signal Amplification by Reversible Exchange (SABRE) Method:
In the field of biochemistry, ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT serves as a substrate in the SABRE method. This technique is employed to develop biocompatible SABRE hyperpolarization, which is a valuable tool for enhancing the sensitivity of magnetic resonance imaging (MRI) and other spectroscopic techniques.
Used in Wheat and Aspergillus Niger Phytase Assay:
ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT is utilized as a substrate in the assay of wheat and Aspergillus niger phytase. Phytase is an enzyme that breaks down phytic acid, which is a major form of phosphorus in plant-based foods. This application is essential for studying the efficiency of phytase enzymes and their potential use in improving the nutritional value of plant-based diets.
Used in Luciferase Assay:
ADENOSINE-5'-MONOPHOSPHATE DISODIUM SALT is employed as a substrate in the luciferase assay to monitor intracellular α-synuclein oligomerization in S1S2 cells. This application is vital for studying the effects of α-synuclein oligomers on the induction of therapeutic hypothermia and neuronal damage in a rat model of cardiac arrest (CA) and resuscitation. Understanding these effects can contribute to the development of novel therapeutic strategies for treating patients with cardiac arrest and related neurological conditions.

Biochem/physiol Actions

Adenosine 5′-monophosphate (5′-AMP) is used to enhance flavor in meat and poultry soups. It is also used as a food additive for specific nutritional purposes. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). Along with inosine monophosphate (IMP), AMP mediates the dissociation of skeletal muscle actomyosin to actin and myosin. Therefore, these two factors may be involved in causing the resolution of rigor mortis in muscles.