14907-98-3 Usage
Description
Brusatol is a natural compound derived from the plant Brucea javanica, which has been found to possess various biological activities and potential therapeutic applications. It is characterized by its ability to modulate cellular pathways and exert protective effects in certain conditions.
Uses
Used in Pharmaceutical Applications:
Brusatol is used as a protective agent for the study of the protective role of Nrf2 (nuclear factor, erythroid 2 like 2) in intestinal ischemia/reperfusion induced injury. This application highlights its potential in the development of treatments for conditions involving oxidative stress and inflammation.
Biochem/physiol Actions
Brusatol promotes Nrf2 (nuclear factor, erythroid 2 like 2 ) ubiquitination and degradation. Brusatol upregulates the expression of multiple ribosomal components and controls macromolecular complex function.
Check Digit Verification of cas no
The CAS Registry Mumber 14907-98-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,9,0 and 7 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 14907-98:
(7*1)+(6*4)+(5*9)+(4*0)+(3*7)+(2*9)+(1*8)=123
123 % 10 = 3
So 14907-98-3 is a valid CAS Registry Number.
InChI:InChI=1/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3
14907-98-3Relevant articles and documents
Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol
Tamura, Sadaaki,Fukamiya, Narihiko,Mou, Xiao-Yang,Mukainaka, Teruo,Tokuda, Harukuni,Nishino, Hoyoku,Tagahara, Kiyoshi,Koike, Kazuo,Lee, Kuo-Hsiung,Okano, Masayoshi
, p. 876 - 878 (2000)
Introduction of a senecioyl group into shinjulactones B and C, and esterification of the diosphenol moiety in brusatol and brucein A enhanced inhibitory effect against Epstein-Barr virus early antigen activation.
Synthesis of (±)-15-deoxybruceolide and conversion of (-)-15-deoxybruceolide into (-)-bruceantin: Total synthesis of bruceantin
Sasaki,Murae,Takahashi
, p. 528 - 540 (2007/10/02)
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