149092-50-2 Usage
Description
AG 825, also known as an organic sulfide, is a compound that consists of 1,3-benzothiazole-2-thiol with a specific group attached to the sulfur atom. It functions as an epidermal growth factor receptor antagonist, making it a significant molecule in the field of pharmaceuticals and medicine.
Uses
Used in Pharmaceutical Industry:
AG 825 is used as a selective ErbB2 (Neu) inhibitor for its ability to target and inhibit the ErbB2 protein, which is often overexpressed in various types of cancer cells. This inhibition can help in controlling the growth and proliferation of cancer cells.
Used in Cancer Treatment:
AG 825 is used as an apoptosis inducer to promote the process of programmed cell death in cancer cells. By inducing apoptosis, AG 825 can contribute to the reduction of tumor size and the prevention of cancer progression.
Used in Anticancer Drug Development:
As an epidermal growth factor receptor antagonist, AG 825 is utilized in the development of new anticancer drugs that can potentially treat various types of cancer by targeting the epidermal growth factor receptor pathway, which is often dysregulated in cancer cells.
Biological Activity
Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 149092-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,0,9 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 149092-50:
(8*1)+(7*4)+(6*9)+(5*0)+(4*9)+(3*2)+(2*5)+(1*0)=142
142 % 10 = 2
So 149092-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
