149105-11-3

Basic information

• Product Name: 4'-HYDROXY-3'-(TRIFLUOROMETHYL)ACETOPHENONE
• Synonyms: 4'-HYDROXY-3'-(TRIFLUOROMETHYL)ACETOPHENONE;4-HYDROXY-3-(TRIFLUOROMETHYL)ACETOPHENONE;1-[4-Hydroxy-3-(trifluoromethyl)phenyl]ethan-1-one, 5-Acetyl-2-hydroxybenzotrifluoride;1-(4-Hydroxy-3-trifluoromethylphenyl)ethanone
• CAS NO: 149105-11-3
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.15
• EINECS: 642-601-6
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 149105-11-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 176-177°C
• Boiling Point: 254.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.335±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.19±0.43(Predicted)
• CAS DataBase Reference: 4'-HYDROXY-3'-(TRIFLUOROMETHYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-HYDROXY-3'-(TRIFLUOROMETHYL)ACETOPHENONE(149105-11-3)
• EPA Substance Registry System: 4'-HYDROXY-3'-(TRIFLUOROMETHYL)ACETOPHENONE(149105-11-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 149105-11-3(Hazardous Substances Data)

Usage

Preparation

Obtained by heating to 180° under nitrogen a mixture of 4-methoxy-3-(trifluoromethyl)acetophenone and pyridinium chloride (39%).

Upstream product

• 444-30-4 2-(trifluoromethyl)phenol 
• 400629-06-3 2-(trifluoromethyl)phenyl acetate 
• 99-93-4 4-Hydroxyacetophenone 
• 2926-29-6 Langlois reagent 

Downstream Products

• 1100767-72-3 1-[4-(pyridin-4-ylmethoxy)-3-trifluoromethyl-phenyl]-ethanone trifluoroacetate 
• 1100767-76-7 4-(4-acetyl-2-trifluoromethyl-phenoxy)-butyric acid ethyl ester 
• 1005515-08-1 1-(3-Bromo-4-hydroxy-5-trifluoromethylphenyl)ethanone 
• 1162128-65-5 1-(4-(hexyloxy)-3-(trifluoromethyl)phenyl)ethanone 
• 1005515-09-2 1-Bromo-5-(1,1-dimethoxyethyl)-2-methoxy-3-trifluoromethylbenzene 
• 1005515-10-5 4-[5-(1,1-Dimethoxyethyl)-2-methoxy-3-trifluoromethylphenyl]morpholine 
• 1005515-11-6 2-bromo-1-(4-methoxy-3-morpholin-4-yl-5-trifluoromethylphenyl)ethanone 
• 1285575-67-8 1-(4-methoxymethoxy-3-trifluoromethylphenyl)ethanone 
• 536975-35-6 4-benzyloxy-3-trifluoromethyl benzoic acid 
• 115933-49-8 4-benzyloxy-3-trifluoromethylbenzoic acid methyl ester 
• 1029097-91-3 4-benzyloxy-3-trifluoromethylbenzoyl chloride 
• 1285575-68-9 3-(4-benzyloxy-3-trifluoromethylbenzoyl)-2,3-dihydro-1,3-benzothiazole 
• 1285575-71-4 3-(4-benzyloxy-3-trifluoromethylbenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole 
• 115933-50-1 methyl 4-hydroxy-3-(trifluoromethyl)benzoate 

Relevant articles and documents

Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.

NOVEL PHENOL DERIVATIVE

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t