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149252-67-5

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149252-67-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 149252-67-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,2,5 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 149252-67:
(8*1)+(7*4)+(6*9)+(5*2)+(4*5)+(3*2)+(2*6)+(1*7)=145
145 % 10 = 5
So 149252-67-5 is a valid CAS Registry Number.

149252-67-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,3S,5R)-3-hydroxy-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolane-2-carbonitrile

1.2 Other means of identification

Product number -
Other names 4'-CN-T

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:149252-67-5 SDS

149252-67-5Downstream Products

149252-67-5Relevant articles and documents

Nucleophilic substitution approach to 4′-substituted thymidines by employing 4′-benzenesulfonyl leaving group

Shimada, Hisashi,Kikuchi, Satoshi,Okuda, Saori,Haraguchi, Kazuhiro,Tanaka, Hiromichi

experimental part, p. 6008 - 6016 (2011/03/18)

Synthesis of 4′-substituted thymidines was investigated based on nucleophilic substitution using organosilicon and organoaluminum reagents. Two substrates having a benzenesulfonyl leaving group at the 4′-position were prepared for this purpose: 1-[4-benzenesulfonyl-3,5-bis-O-(tert-butyldimethylsilyl)-2-deoxy-α-l-threo-pentofuranosyl]thymine (8α) and the 4′-(benzenesulfonyl)thymidine derivative (8β). The reaction of 8α with organosilicon reagents (Me3SiCH2CH{double bond, long}CH2 and Me3SiN3) in combination with SnCl4 gave preferentially the 4′-substituted β-d-isomer: the 4′-allyl (12β) and 4′-azido (15β) derivatives, respectively. The reaction of 8α with AlMe3, however, gave the 4′-methyl-α-l-isomer (16α) as the major product, presumably through an ion pair mechanism. By employing the substrate 8β in this reaction, the 4′-methylthymidine derivative (16β) was obtained exclusively in high yield. The 4′-ethyl (20β) and 4′-cyano (24β) derivatives were also synthesized by reacting 8β with the respective organoaluminum reagent.

Synthesis of 4'-cyanothymidine and analogs as potent inhibitors of HIV

O-Yang,Wu,Fraser-Smith,Walker

, p. 37 - 40 (2007/10/02)

4'-Cyanothymidine inhibits HIV in A301 (Alex) cells with an IC50 of 0.002 μM. The uridine and cytidine analogs show similar potencies.

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