149289-30-5 Usage
Description
D,L N-Desmethylvenlafaxine is a monomethoxybenzene derivative and a metabolite of Venlafaxine, which is a selective serotonin noradrenaline reuptake inhibitor (SNRI). It is an off-white low melting solid and plays a significant role in the pharmacological effects of Venlafaxine.
Uses
Used in Pharmaceutical Industry:
D,L N-Desmethylvenlafaxine is used as an antidepressant for the treatment of major depressive disorder. As a metabolite of Venlafaxine, it contributes to the overall therapeutic effects of the parent drug by inhibiting the reuptake of serotonin and noradrenaline in the brain, thereby increasing their levels and improving mood and reducing depressive symptoms.
Check Digit Verification of cas no
The CAS Registry Mumber 149289-30-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,2,8 and 9 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 149289-30:
(8*1)+(7*4)+(6*9)+(5*2)+(4*8)+(3*9)+(2*3)+(1*0)=165
165 % 10 = 5
So 149289-30-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H25NO2/c1-17-12-15(16(18)10-4-3-5-11-16)13-6-8-14(19-2)9-7-13/h6-9,15,17-18H,3-5,10-12H2,1-2H3
149289-30-5Relevant articles and documents
DERIVATIVES OF (-)-VENLAFAXINE AND METHODS OF PREPARING AND USING THE SAME
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, (2015/11/23)
Methods of preparing, and compositions comprising, derivatives of (?)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.
AN IMPROVED PROCESS FOR THE PREPARATION OF VENLAFAXINE AND ITS ANALOGS
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Page/Page column 16, (2008/12/05)
A novel single step process for the synthesis of venlafaxine of formula I and N-desmethylvenlafaxine of formula II from 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile [cyano-intermediate] of formula V V comprising reacting 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile with an alkylamine and/or its salt in a solvent in the presence of a transition metal catalyst, under hydrogen atmosphere.
