149365-95-7

Basic information

• Product Name: [1,2-Bis-(4-fluoro-phenyl)-ethyl]-(2,2-diethoxy-ethyl)-amine
• Synonyms: [1,2-Bis-(4-fluoro-phenyl)-ethyl]-(2,2-diethoxy-ethyl)-amine
• CAS NO: 149365-95-7
• Molecular Weight: 349.421
• Mol File: 149365-95-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1,2-Bis-(4-fluoro-phenyl)-ethyl]-(2,2-diethoxy-ethyl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [1,2-Bis-(4-fluoro-phenyl)-ethyl]-(2,2-diethoxy-ethyl)-amine(149365-95-7)
• EPA Substance Registry System: [1,2-Bis-(4-fluoro-phenyl)-ethyl]-(2,2-diethoxy-ethyl)-amine(149365-95-7)

Safety Data

• Hazardous Substances Data: 149365-95-7(Hazardous Substances Data)

Upstream product

• 133235-80-0 (-)-1,2-bis(4-fluorophenyl)ethylamine 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 366-68-7 4,4'-difluorodeoxybenzoin 
• 462-06-6 fluorobenzene 

Relevant articles and documents

10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands

IDDC (3, 10,5-(iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene) and a series of substituted derivatives were synthesized and evaluated in vitro for their ability to displace tritiated MK-801 ([3H]-2) from its specific binding site in guinea pig brain homogenate. Substitution at the 3- position of 3 with bromine, chlorine, and fluorine led to increased binding affinity. In contrast, substitution of donor groups at the 3-position gave decreased binding affinities, as did all substitutions at the 7-position and on nitrogen. Where racemic mixtures were resolved, the (+)-optical antipodes were more active than their enantiomers or racemates. The most active ligand found in this study was (+)-13e (IC50 = 15.5 ± 4.5 nM). The affinity of (+)-13e for the PCP receptor makes it among the most potent ligands known. In vitro neuroprotection was demonstrated by 3, (+)-3, and (+)-6 (N-Me-IDDC) against glutamate-induced cell death in rat hippocampal cells.