149394-66-1

Basic information

• Product Name: Cidofovir
• Synonyms: Cidofovir hydrate (1:2);P-[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid hydrate (1:2);Cidofovir hydrate;Drg-0145;Gs-0504;Phosphonic acid, ((2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy)methyl)-, dihydrate, (S)-;Unii-jil713Q00n;(S)-[1-(4-AMino-2-oxo-pyriMidin-1(2H)-yl)-3-hydroxy-propan-2-yl]oxyMethylphosphonic acid dihydrate
• CAS NO: 149394-66-1
• Molecular Formula: C8H14N3O6P
• Molecular Weight: 279.187021
• EINECS: 1308068-626-2
• Product Categories: Amines;Anti-virals;Heterocyles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
• Mol File: 149394-66-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 609.5ºC at 760mmHg
• Flash Point: 322.4ºC
• Appearance: /
• Density: 1.76g/cm3
• Vapor Pressure: 2.11E-17mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Sparingly), Water (Sparingly)
• CAS DataBase Reference: Cidofovir(CAS DataBase Reference)
• NIST Chemistry Reference: Cidofovir(149394-66-1)
• EPA Substance Registry System: Cidofovir(149394-66-1)

Safety Data

• Hazardous Substances Data: 149394-66-1(Hazardous Substances Data)

Usage

Description

Cidofovir, also known as (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, is a synthetic nucleotide analogue antiviral medication. It is a white solid with potent antiviral activity against a range of viruses, including cytomegalovirus (CMV), herpes simplex virus (HSV), and human papillomavirus (HPV). Cidofovir works by inhibiting viral DNA polymerase, thereby preventing viral replication and transcription.

Uses

Used in Antiviral Treatment:
Cidofovir is used as an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selectively inhibiting viral DNA polymerase, leading to the prevention of viral replication and transcription.
Used in Treatment of Acyclovir-Resistant Herpes:
Cidofovir is utilized as an alternative treatment for acyclovir-resistant herpes infections, providing an effective option for patients who do not respond to traditional antiviral therapies.
Used in Intralesional Therapy for HPV-Related Papillomatosis:
Cidofovir serves as a complementary intralesional therapy for the treatment of papillomatosis caused by human papillomavirus (HPV), offering a targeted approach to managing this condition.
Used in Pain Management:
Cidofovir Dihydrate is employed in the treatment of pain, often in combination with other analgesics, to provide effective pain relief for patients.
Used in Pharmaceutical Industry:
Cidofovir is used as an antiviral agent in the pharmaceutical industry for the development of medications targeting various viral infections, particularly those caused by CMV, HSV, and HPV.

InChI:InChI=1/C8H14N3O6P.2H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);2*1H2/t6-;;/m0../s1