149402-51-7

Basic information

• Product Name: 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid
• Synonyms: 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid;2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a;(3S,4S)-14-Ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A;Photochlor;Photochlor (HPPH);3-Phorbinepropanoic acid, 14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18 -tetramethyl-20-oxo-, (3S,4S)-;Sulcardine
• CAS NO: 149402-51-7
• Molecular Formula: C39H48N4O4
• Molecular Weight: 636.82282
• Mol File: 149402-51-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 980.8°Cat760mmHg
• Flash Point: 547°C
• Appearance: /
• Density: 1.184
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid(149402-51-7)
• EPA Substance Registry System: 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid(149402-51-7)

Safety Data

• Hazardous Substances Data: 149402-51-7(Hazardous Substances Data)

Usage

Description

14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid is a complex organic compound with a unique molecular structure. It is characterized by its phorbine core, which is a type of macrocyclic compound, and various substituents that contribute to its specific properties and potential applications.

Uses

Used in Anticancer Applications:
14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid is used as an anticancer agent for its potential to target and kill cancer cells. The compound may modulate oncological signaling pathways, similar to gallotannin, and could be effective against various types of solid malignancies.
Used in Photodynamic Therapy (PDT):
In the field of photodynamic therapy, 14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid is used as a photosensitizer. When administered systemically and stimulated with light at a specific wavelength, it accumulates in tumor cells and generates reactive oxygen species (ROS), leading to necrosis within the tumor. This application is similar to the use of HPPH in PDT, where it increases survival rates in animal models of cancer and works synergistically with other chemotherapeutic agents.
Used in Drug Delivery Systems:
14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid may also be utilized in the development of novel drug delivery systems to enhance its bioavailability and therapeutic outcomes. Like gallotannin, this compound could be incorporated into organic and metallic nanoparticles for improved delivery to cancer cells, potentially overcoming limitations associated with its use.

InChI:InChI=1/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,40-41H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1