149440-35-7

Basic information

• Product Name: 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, 10-[(4-aminophenyl)methyl]-
• Synonyms: DO 3A
• CAS NO: 149440-35-7
• Molecular Formula: C21H33 N5 O6
• Molecular Weight: 451.523
• Mol File: 149440-35-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, 10-[(4-aminophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, 10-[(4-aminophenyl)methyl]-(149440-35-7)
• EPA Substance Registry System: 1,4,7,10-Tetraazacyclododecane-1,4,7-triaceticacid, 10-[(4-aminophenyl)methyl]-(149440-35-7)

Safety Data

• Hazardous Substances Data: 149440-35-7(Hazardous Substances Data)

Upstream product

• 114873-52-8 1,4,7-tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane 
• 607706-70-7 4-nitrobenzyl DO₃A tert-butyl ester 
• 122555-91-3 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 607706-71-8 1,4,7-tris(tert-butoxycarbonylmethyl)-10-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane 
• 294-90-6 1,4,7,10-tetraazacyclododecan 

Relevant articles and documents

Lanthanide-based protease activity sensors for time-resolved fluorescence measurements

Lanthanide-based luminescent sensors are noteworthy because their long-lifetime luminescence enables time-resolved fluorescence measurements. After exploring suitable antenna groups, we designed and synthesized lanthanide-based luminogenic sensors detecti

A convenient, novel approach for the synthesis of polyaza macrocyclic bifunctional chelating agents

The convenient synthetically useful bifunctional chelating agents, (10-p-aminobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (p-ABz-DO3A) 3 and (11-p-aminobenzyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-triacetate (p-ABz-TE3A) 6, were obtained by reaction of an ethyl bromoacetate with 1,4,7,10-tetraazacyclododecane and 1,4,8,11-tetraazacyclotetradecane followed by reaction with nitrobenzyl bromide. This method proved more efficient than any described in the literature since the overall yield in a two-step synthesis sequence starting from tetraazamacrocycles was 68%.