149777-00-4

Basic information

• Product Name: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER
• Synonyms: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER;DIMETHYL TETRAHYDROPYRAN-4,4-DICARBOXYLATE;Tetrahydropyran-4,4-dicarboxylicAcidDimethylEst;4H-Pyran-4,4-dicarboxylicacid;DiMethyl dihydro-2H-pyran-4,4(3H)-dicarboxylate;Dimethyl tetrahydro-4H-pyran-4,4-dicarboxylate;Tetrahydro-2H-pyran-4,4-dicarboxylic acid dimethyl ester;Tetrahydro-4H-pyran-4,4-dicarboxylic acid dimethyl ester
• CAS NO: 149777-00-4
• Molecular Formula: C9H14O5
• Molecular Weight: 202.20446
• EINECS: 1308068-626-2
• Mol File: 149777-00-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 238.235°C at 760 mmHg
• Flash Point: 96.744°C
• Appearance: /
• Density: 1,18 g/cm3
• Vapor Pressure: 0.043mmHg at 25°C
• Refractive Index: 1.4530 to 1.4560
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(149777-00-4)
• EPA Substance Registry System: TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER(149777-00-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 149777-00-4(Hazardous Substances Data)

Usage

General Description

Tetrahydropyran-4,4-dicarboxylic acid dimethyl ester is a chemical compound with the molecular formula C10H16O5. It is commonly used as a building block in organic synthesis and is known for its potential as a pharmaceutical intermediate. TETRAHYDROPYRAN-4,4-DICARBOXYLIC ACID DIMETHYL ESTER is a colorless liquid with a slightly fruity odor, and it is soluble in most organic solvents. It is important to handle this substance with care, as it may cause irritation to the skin, eyes, and respiratory system. Overall, tetrahydropyran-4,4-dicarboxylic acid dimethyl ester has several industrial applications and is a valuable tool in the field of organic chemistry.

InChI:InChI=1/C9H14O5/c1-12-7(10)9(8(11)13-2)3-5-14-6-4-9/h3-6H2,1-2H3

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 923020-93-3 4-(methoxycarbonyl) dihydro-2H-pyran-4-carboxilic acid 
• 95283-42-4 4,4-bis-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran 
• 89975-77-9 (tetrahydro-2H-pyran-4,4-diyl)dimethanol 
• 834914-37-3 methyl 4-(hydroxymethyl)tetrahydro-2H-pyran-4-carboxylate 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Relevant articles and documents

Quinoline multi-target kinase inhibitor with antitumor activity and preparation method thereof

The invention relates to a quinoline multi-target kinase inhibitor with antitumor activity and a preparation method thereof. A general structural formula of the compound is shown in a formula (I) described in the specification. In vitro cell experiments verify that the compound provided by the invention has strong in vitro inhibitory activity on five common tumor cell lines, namely human thyroid carcinoma SW579, human hepatic carcinoma HepG2, human lung adenocarcinoma A549, human colorectal adenocarcinoma HCT116 and human gastric carcinoma MKN45, antitumor activities of most of target compounds are better than or equivalent to that of a positive control drug Cabozantinib, and the in vitro cell experiments verify that the compound provided by the invention has strong inhibitory activity on two kinases KDR and MET, so that the compound provided by the invention has a broad application prospect in preparation of a new antitumor drug.