149819-58-9 Usage
Description
[(2S,5S)-5-(6-chloro-9H-purin-9-yl)-1,3-oxathiolan-2-yl]methanol, also known as abacavir, is a pharmaceutical compound that belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs). It is characterized by its ability to interfere with the replication of the HIV virus within the human body, making it a crucial component in the treatment of HIV/AIDS.
Uses
Used in Pharmaceutical Industry:
Abacavir is used as an antiviral medication for the treatment of HIV/AIDS. It functions by inhibiting the activity of reverse transcriptase, a viral enzyme essential for the replication of the HIV virus. This action helps to suppress the viral load and slows down the progression of the disease.
Used in Combination Therapy:
Abacavir is often used in combination with other antiretroviral drugs to enhance the effectiveness of HIV treatment. This combination therapy approach helps to prevent the development of drug resistance and allows for better management of the infection.
Check Digit Verification of cas no
The CAS Registry Mumber 149819-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,8,1 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 149819-58:
(8*1)+(7*4)+(6*9)+(5*8)+(4*1)+(3*9)+(2*5)+(1*8)=179
179 % 10 = 9
So 149819-58-9 is a valid CAS Registry Number.
149819-58-9Relevant articles and documents
Structure-Activity Relationships of β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanyl Nucleosides as Potential Anti-HIV Agents
Jeong, Lak S.,Schinazi, Raymond F.,Beach, J. Warren,Kim, Hea O.,Shanmuganathan, Kirupathevy,et al.
, p. 2627 - 2638 (2007/10/02)
The β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanylpyrimidine and -purine nucleosides with natural nucleoside configuration were synthesized and evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells.The key intermediate 14, which was uti
