149865-84-9 Usage
Description
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is a chemical compound with a molecular formula of C10H9NS. It is an isothiocyanate derivative of indene, a bicyclic aromatic hydrocarbon. 1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is a yellowish to light brown solid at room temperature and is insoluble in water but soluble in organic solvents such as ether and acetone.
Uses
Used in Organic Synthesis:
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is used as a reagent in organic synthesis for its unique isothiocyanate group, which allows for the formation of various chemical compounds.
Used in Chemical Reactions:
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is utilized as a reagent in chemical reactions due to its specific properties, enabling the synthesis of a range of products.
Used in Pharmaceutical Production:
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is used as a building block in the production of pharmaceuticals, given its potential to form a variety of medicinally relevant compounds.
Used in Pesticide Production:
It is employed in the creation of pesticides, leveraging its chemical structure to target and control pests effectively.
Used in Polymer Production:
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) is used in the synthesis of polymers, contributing to the development of new materials with specific properties.
Used in Agriculture:
1H-Indene,2,3-dihydro-5-isothiocyanato-(9CI) has potential applications in agriculture, although further research is needed to fully explore these possibilities.
Used in Medicine:
It also holds potential for use in medicine, with ongoing research aimed at uncovering its full range of applications in this field.
Check Digit Verification of cas no
The CAS Registry Mumber 149865-84-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,8,6 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 149865-84:
(8*1)+(7*4)+(6*9)+(5*8)+(4*6)+(3*5)+(2*8)+(1*4)=189
189 % 10 = 9
So 149865-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NS/c12-7-11-10-5-4-8-2-1-3-9(8)6-10/h4-6H,1-3H2
149865-84-9Relevant articles and documents
Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors
Bae, Yun Soo,Choi, Sun,Park, Jung Jae,Joo, Jung Hee,Cui, Minghua,Cho, Hyunsung,Lee, Won Jae,Lee, Sang Hyup
, p. 4144 - 4151 (2016)
We report the synthesis of novel 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins 3, and their biological evaluation using NADPH oxidase (NOX) 1 and 4. Based on structural and pharmacophore analyses of known inhibitors such as hydroxypyrazole 2, we e
Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: Discovery and optimization of dihydrothiophenone derivatives
Xu, Minghao,Zhu, Junsheng,Diao, Yanyan,Zhou, Hongchang,Ren, Xiaoli,Sun, Deheng,Huang, Jin,Han, Dongmei,Zhao, Zhenjiang,Zhu, Lili,Xu, Yufang,Li, Honglin
, p. 7911 - 7924 (2013/11/06)
Taking the emergence of drug resistance and lack of effective antimalarial vaccines into consideration, it is of significant importance to develop novel antimalarial agents for the treatment of malaria. Herein, we elucidated the discovery and structure-activity relationships of a series of dihydrothiophenone derivatives as novel specific inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). The most promising compound, 50, selectively inhibited PfDHODH (IC50 = 6 nM, with >14 000-fold species-selectivity over hDHODH) and parasite growth in vitro (IC50 = 15 and 18 nM against 3D7 and Dd2 cells, respectively). Moreover, an oral bioavailability of 40% for compound 50 was determined from in vivo pharmacokinetic studies. These results further indicate that PfDHODH is an effective target for antimalarial chemotherapy, and the novel scaffolds reported in this work might lead to the discovery of new antimalarial agents.