149908-53-2 Usage
Description
Azimilide, also known as E-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, is a class III anti-arrhythmic agent that significantly blocks the delayed rectifier potassium current, including the Ikr component. It is characterized by its ability to block multiple channels, which may be due to the absence of the methane sulfonamide group found in other class III agents. This unique property allows Azimilide to provide consistent class III anti-arrhythmic effects at any heart rate.
Uses
Used in Pharmaceutical Industry:
Azimilide is used as a cardiac depressant for the treatment of various arrhythmias. Its ability to block both Ikr and Iks potassium currents makes it an effective anti-arrhythmic agent, helping to regulate heart rate and prevent irregular heartbeats.
Used in Cardiology:
Azimilide is used as an anti-arrhythmic agent in cardiology to manage and treat patients with atrial fibrillation and other related heart rhythm disorders. By blocking the delayed rectifier potassium current, it helps maintain a consistent heart rate and reduces the risk of life-threatening arrhythmias.
Therapeutic Function
Antiarrhythmic
Clinical Use
Azimilde is another Class III antiarrhythmic agent structurally unrelated to any of the above agents. Azimilide is not available in the United States; it is only available in Europe. Following
oral administration, the drug is completely absorbed, with no effect of food. Protein binding is 94%.
It is metabolized in the liver to an active carboxylate metabolite, but its concentration in plasma is
less than 5% of the parent compound. Thus, it is considered to be therapeutically inactive. Renal
excretion is approximately 10%. Its elimination half-life is 3 to 4 days.
Enzyme inhibitor
This class ΙΙΙ antiarrhythmic drug and ion channel blocker (FW = 457.95 g/mol; CAS 149908-53-2), also known by the code name NE-10064 and systematic name, 1-({(E)-[5-(4-chlorophenyl)furan-2-yl]methylidene} amino)-3-[4-(4-methylpiperazin-1-yl)butyl]-imidazolidine-2,4-dione, blocks both the slow-activating IKs and rapidly activating IKr components of the delayed rectifier potassium current, distinguishing its action from conventional potassium channel blockers such as sotalol and dofetilide,which block only IKr. Azimilide prolongs the cardiac refractory period in a dose-dependent manner, as manifested by increases in action potential duration, QTc interval, and effective refractory period.
Check Digit Verification of cas no
The CAS Registry Mumber 149908-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,9,0 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 149908-53:
(8*1)+(7*4)+(6*9)+(5*9)+(4*0)+(3*8)+(2*5)+(1*3)=172
172 % 10 = 2
So 149908-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16H,2-3,10-15,17H2,1H3/b25-16+