149967-30-6

Basic information

• Product Name: 1H-Pyrrolo[3,4-b]quinoline-1,3(2H)-dione
• CAS NO: 149967-30-6
• Molecular Formula: C11H6N2O2
• Molecular Weight: 198.181
• Mol File: 149967-30-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolo[3,4-b]quinoline-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,4-b]quinoline-1,3(2H)-dione(149967-30-6)
• EPA Substance Registry System: 1H-Pyrrolo[3,4-b]quinoline-1,3(2H)-dione(149967-30-6)

Safety Data

• Hazardous Substances Data: 149967-30-6(Hazardous Substances Data)

Upstream product

• 643-38-9 quinoline-2,3-dicarboxylic acid 

Relevant articles and documents

Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: Modification of the P1 and P2' residues

Systematic modification of the presumed P1 side chain in a series of (carboxyalkyl)amino-based inhibitors of matrix metalloproteinases enabled identification of the 2-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)ethyl group as a preferred substituent imparting potent inhibition of the enzymes collagenase and gelatinase. It was subsequently found that the P2'-P3' residues in this series could be replaced by small non-peptide residues, while maintaining inhibitory potency. The imide group in this series of compounds can undergo autocatalytic hydrolysis under neutral conditions.