150018-27-2

Basic information

• Product Name: C₂₈H₂₆N₂O₄S
• CAS NO: 150018-27-2
• Molecular Weight: 486.591
• Mol File: 150018-27-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₂₆N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₂₆N₂O₄S(150018-27-2)
• EPA Substance Registry System: C₂₈H₂₆N₂O₄S(150018-27-2)

Safety Data

• Hazardous Substances Data: 150018-27-2(Hazardous Substances Data)

Upstream product

• 76-83-5 trityl chloride 
• 5580-20-1 2'-deoxy-4-thiouridine 
• 1277165-04-4 4-thio-5',3'-di-O-p-tolyl-2'-deoxyuridine 
• 29725-45-9 5',3'-di-O-p-tolyl-2'-deoxyuridine 

Downstream Products

• 1277164-90-5 C₂₉H₂₈N₂O₄S 

Relevant articles and documents

Modified 5'-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase

2'-Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum enzyme. Herein we report further structure-activity studies; in particular, variations of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active compounds. However, there is a clear requirement for the uracil base for activity, because modifications of the uracil ring result in loss of enzyme inhibition and significant decreases in antiplasmodial action. Fewer trips to the dUMP: dUTPase is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this P.falciparum enzyme. Herein we report further structure-activity studies of the 5'-trityl group, the introduction of various substituents at the 3'-position of deoxyuridine, and modifications of the base.