150187-64-7

Basic information

• Product Name: 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole
• Synonyms: 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole
• CAS NO: 150187-64-7
• Molecular Weight: 0
• EINECS: -0
• Mol File: 150187-64-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole(150187-64-7)
• EPA Substance Registry System: 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole(150187-64-7)

Safety Data

• Hazardous Substances Data: 150187-64-7(Hazardous Substances Data)

Usage

General Description

The chemical 1-(tetrahydro-2H-pyran-2-yl)-5-nitro-1H-indazole is a compound that consists of a tetrahydro-2H-pyran-2-yl group attached to a 5-nitro-1H-indazole group. It is a heterocyclic compound with potential pharmacological properties. The tetrahydro-2H-pyran-2-yl group provides a cyclic structure containing oxygen, while the 5-nitro-1H-indazole group contains a nitrogen and a nitro functional group. These structural features may impart specific chemical and biological activities to the compound, making it potentially useful in a variety of applications such as drug discovery and development. Further research is needed to fully understand the properties and potential uses of this compound.

Upstream product

• 5401-94-5 5-nitroindazole 
• 110-87-2 3,4-dihydro-2H-pyran 
• 142-68-7 TETRAHYDROPYRANE 

Downstream Products

• 1574358-60-3 1-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-((1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea 
• 1574357-80-4 1-(4-((2-((1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(tert-butyl)-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrazol-5-yl)urea 
• 478832-10-9 1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine 

Relevant articles and documents

Nitrosation of derivatives of hydrazines, VIII: Novel oxidative C-N-coupling of indazoles and benzotriazoles with cyclic ethers

Allopurinol, nitroindazoles and 5-nitrobenzotriazoles react with cyclic ethers under oxidation with nitrosyl-tetrafluoroborate or 2,3-dichloro-5,6-dicyanobenzoquinone yielding C-N-coupled products.

A mild and efficient THP protection of indazoles and benzyl alcohols in water

A mild and efficient method for THP protection of indazoles and benzyl alcohols has been developed in water, the most environmentally friendly solvent, in which Tween 20 (2% w/w) was added to form aqueous micelles to increase the solubility of starting materials. This aqueous protocol allowed the reaction to proceed smoothly at room temperature and with only 1.2 equiv of DHP, providing moderate to good yields of THP protected products for a wide scope of substrates. In addition, the methodology was highly practical in the large-scale synthesis (1 g synthesis of 2c as an example), wherein the convenient work-up and purification procedure (simple filtration) made the protocol even more attractive.

PYRAZOLE DERIVATIVES AS P38 MAP INHIBITORS

Compounds of formula (I) wherein R1, R2, J, Q, V, X, Y and Z are defined herein are disclosed. The compounds are inhibitors of the family of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha sub-type thereof, and of Syk kinase and the Src family of tyrosine kinases. The compounds may be used in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, in particular inflammatory diseases of the lung, such as asthma and COPD, as well as those of the gastrointestinal tract, such as ulcerative colitis and Crohn's disease and of the eye, such as uveitis.