1503-98-6

Basic information

• Product Name: CYCLOBUTANECARBOXAMIDE
• Synonyms: CYCLOBUTANECARBOXAMIDE;Cyclobutanecarboxilic acidaMide
• CAS NO: 1503-98-6
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.13
• Product Categories: Cycloalkanes
• Mol File: 1503-98-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 155 °C
• Boiling Point: 254.7 °C at 760 mmHg
• Flash Point: 107.8 °C
• Appearance: /
• Density: 1.108 g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.74±0.20(Predicted)
• CAS DataBase Reference: CYCLOBUTANECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOBUTANECARBOXAMIDE(1503-98-6)
• EPA Substance Registry System: CYCLOBUTANECARBOXAMIDE(1503-98-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1503-98-6(Hazardous Substances Data)

Usage

General Description

Cyclobutanecarboxamide, also known as cyclobutylcarboxamide, is a chemical compound with the molecular formula C5H9NO. It is a white, crystalline solid that is insoluble in water but soluble in organic solvents. Cyclobutanecarboxamide is primarily used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is also used in the manufacturing of polymers and as a building block for organic synthesis. Due to its low water solubility and potential for bioaccumulation, cyclobutanecarboxamide may have environmental and health implications if not handled and disposed of properly.

InChI:InChI=1/C5H9NO/c6-5(7)4-2-1-3-4/h4H,1-3H2,(H2,6,7)

Upstream product

• 5006-22-4 Cyclobutanecarbonyl chloride 
• 23745-75-7 3-chlorobicyclobutane-1-carbonitrile 
• 3721-95-7 Cyclobutanecarboxylic acid 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 75-05-8 acetonitrile 

Downstream Products

• 3019-25-8 1-cyclobutylethanone 
• 4426-11-3 cyclobutanecarbonitrile 
• 2516-34-9 cyclobutylamine 
• 15907-95-6 N-phenylcyclobutanecarboxamide 
• 56700-66-4 tert-butyl cyclobutylcarbamate 
• 102520-42-3 cyclobutylamine 4-methylbenzene sulfonate 
• 6291-01-6 cyclobutanamine hydrochloride 
• 3721-95-7 Cyclobutanecarboxylic acid 
• 14924-53-9 ethyl cyclobutylcarboxylate 
• 4415-83-2 cyclobutylmethylamine 
• 25774-35-0 cyclobutanecarboxylic anhydride 
• 5006-22-4 Cyclobutanecarbonyl chloride 
• 156589-97-8 cyclobutancarbothioamide 
• 1620483-46-6 C₃₂H₃₂FN₃O₅ 

Relevant articles and documents

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One-Pot Anodic Conversion of Symmetrical Bisamides of Ethylene Diamine to Unsymmetrical gem-Bisamides of Methylene Diamine

Symmetrical bisamides of ethylene diamine of type ArCONHCH2CH2NHCOAr undergo anodic C-C bond cleavage in acetonitrile-LiClO4 under controlled-potential electrolysis. The electrogenerated carbocation intermediates react with the solvent acetonitrile to afford unsymmetrical gem-bisamides of type ArCONHCH2NHCOMe in a one-pot reaction. The yields of the latter products are moderate (up to 60%). Other minor products involve two symmetrical gem-bisamides of type ArCONHCH2NHCOAr and MeCONHCH2NHCOMe and fragmentation products (e.g., ArCONHCHO, ArCONH2, and ArCN).

SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS

The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.