15049-85-1

Basic information

• Product Name: (1-aminoethylidene)bisphosphonic acid
• Synonyms: (1-aminoethylidene)bisphosphonic acid;Einecs 239-120-5
• CAS NO: 15049-85-1
• Molecular Formula: C₂H₉NO₆P₂
• Molecular Weight: 205.043482
• EINECS: 239-120-5
• Mol File: 15049-85-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 540.3°Cat760mmHg
• Flash Point: 280.6°C
• Appearance: /
• Density: 1.979g/cm³
• Vapor Pressure: 4.16E-13mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: (1-aminoethylidene)bisphosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1-aminoethylidene)bisphosphonic acid(15049-85-1)
• EPA Substance Registry System: (1-aminoethylidene)bisphosphonic acid(15049-85-1)

Safety Data

• Hazardous Substances Data: 15049-85-1(Hazardous Substances Data)

Usage

Description

(1-aminoethylidene)bisphosphonic acid, also known as alendronic acid, is a bisphosphonate drug characterized by its unique chemical structure that includes two phosphonate groups and an aminoethylidene group. This structure endows the compound with the ability to bind to calcium in bones and inhibit the activity of osteoclasts, the cells responsible for bone resorption. As a result, it plays a crucial role in the management of bone health by slowing down bone breakdown and increasing bone density, which helps prevent fractures and maintain bone strength.

Uses

Used in Pharmaceutical Industry:
(1-aminoethylidene)bisphosphonic acid is used as a therapeutic agent for the treatment of osteoporosis and other bone-related diseases. Its application is based on its ability to slow down bone breakdown and increase bone density, which helps prevent fractures and maintain bone strength in patients.
Used in Postmenopausal Women's Health:
(1-aminoethylidene)bisphosphonic acid is used as a preventive measure for hip, spine, and other fractures in postmenopausal women with osteoporosis. Its application is due to its effectiveness in reducing the risk of such fractures, making it an important medication for the management of bone health in this demographic.

InChI:InChI=1/C2H9NO6P2/c1-2(3,10(4,5)6)11(7,8)9/h3H2,1H3,(H2,4,5,6)(H2,7,8,9)

Upstream product

• 75-05-8 acetonitrile 
• 762-04-9 phosphonic acid diethyl ester 
• 60-35-5 acetamide 
• 1605320-74-8 tetrakis(trimethylsilyl) (1-aminoethane-1,1-diyl) bisphosphonate 

Downstream Products

• 13598-36-2 phosphonic Acid 

Relevant articles and documents

Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase

We have investigated the effect of a series of 1-amino-1,1-bisphosphonates derived from fatty acids against proliferation of the clinically more relevant form of Trypanosoma cruzi, the causative agent of American trypanosomiasis (Chagas' disease). Some of these drugs were potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at low micromolar level. Cellular activity was associated with the inhibition of enzymatic activity of T. cruzi farnesyl pyrophosphate synthase. As bisphosphonate-containing drugs are FDA-approved for the treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases.

1-acetamido-ethylidene-1,1-bisphosphonate and preparation method and application thereof

The invention discloses a 1-acetamido-ethylidene-1,1-bisphosphonate, and particularly discloses a 1-acetamido-ethylidene-1,1-calcium diphosphate. A structural formula of the 1-acetamido-ethylidene-1,1-bisphosphonate is as shown in a formula (I). The invention further discloses a preparation method of the compound in the formula (I). The compound in the formula (I) has an anti-radiation effect, especially has an excellent discharge-facilitating effect on strontium, is stable in property and good in water solubility, and can be used as a high-efficiency and low-toxicity discharge-facilitating drug for pollution in radioactive strontium.

Synthesis of substituted N-formylaminomethylenediphosphonates and their derivatives

The convenient methods for the synthesis of new trimethylsilyl esters of aminomethylenediphosphonic acids are elaborated. The new substituted N-formylaminomethylenediphosphonates are obtained via the interaction of trimethylsilyl esters of methylenediphosphonic acids with a mixture of triethyl orthoformate and ethanol. Also boron trifluoride-diethyl etherate as an effective catalyst is used for the interaction of hydrochlorides of ethoxymethylene imines with diethyl trimethylsilyl phosphite. The corresponding aminomethylenediphosphonic acids are presented.

Synthesis of new types of aminomethylenediphosphorus-containing acids and their derivatives

Convenient methods for synthesis of various aminomethylenediphosphorus-containing acids and their derivatives starting from available trimethylsilyl esters of hypophosphorous and phosphorous acids, ethoxymethyleneimine hydrochlorides, and N-substituted formamides have been proposed. Selected properties of the obtained compounds have been examined.