150582-52-8

Basic information

• Product Name: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one
• Synonyms: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one
• CAS NO: 150582-52-8
• Molecular Weight: 313.199
• Mol File: 150582-52-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one(150582-52-8)
• EPA Substance Registry System: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one(150582-52-8)

Safety Data

• Hazardous Substances Data: 150582-52-8(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 684-16-2 Hexafluoroacetone 

Downstream Products

• 367952-49-6 (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-methyl-1,3-oxazolidin-5-one 
• 74163-81-8 L-Tic-OH 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 367952-46-3 (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one 
• 2862-51-3 (3S,6S)-3,6-dibenzylpiperazine-2,5-dione 

Relevant articles and documents

Asymmetric pictet-spengler reactions: Synthesis of 1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) chimeras

A preparatively simple diastereoselective synthesis of the amino acid chimera (1S,3S)-1,2,3,4-tetrahydroisoquinoline-1,3-dicarboxylic acid from hexafluoroacetone-protected phenylalanine and glyoxylic acid hydrate via Pictet-Spengler reaction is described. The potential of the reaction of hexafluoroacetone-protected phenylalanine with other aldehydes was scrutinized.