1506-47-4

Basic information

• Product Name: ETHYLIMINUM
• Synonyms: ETHYLIMINUM;SALOR-INT L163228-1EA;1,2-bis(3,5-dioxopiperazin-1-yl)ethane;4,4'-Ethylenedi(2,6-piperazinedione);ICRF-154;NSC-129942;4-[2-(3,5-diketopiperazin-1-yl)ethyl]piperazine-2,6-quinone;4-[2-(3,5-dioxopiperazin-1-yl)ethyl]piperazine-2,6-dione
• CAS NO: 1506-47-4
• Molecular Formula: C10H14N4O4
• Molecular Weight: 254.24
• Mol File: 1506-47-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 295-300 °C
• Boiling Point: 539.9 °C at 760 mmHg
• Flash Point: 280.3 °C
• Appearance: /
• Density: 1.361 g/cm³
• Vapor Pressure: 1.01E-11mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: Room Temperature
• Solubility: Dichloromethane/Methanol (8:2); DMSO; Methanol (heated)
• PKA: 10.71±0.20(Predicted)
• CAS DataBase Reference: ETHYLIMINUM(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYLIMINUM(1506-47-4)
• EPA Substance Registry System: ETHYLIMINUM(1506-47-4)

Safety Data

• Hazardous Substances Data: 1506-47-4(Hazardous Substances Data)

Usage

Description

ETHYLIMINUM, also known as 1,2-Bis(3,5-dioxo-1-piperazinyl)ethane, is an intermediate compound in the synthesis of Bimolane (B386845). It is characterized by its catalytic inhibition of topoisomerase II, a crucial enzyme in DNA replication. This unique property makes ETHYLIMINUM a promising candidate for various pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
ETHYLIMINUM is used as an intermediate in the synthesis of Bimolane (B386845) for its role in inhibiting topoisomerase II, which is essential in DNA replication. This inhibition has been found to be effective in the treatment of various medical conditions.
Used in Cancer Treatment:
ETHYLIMINUM is used as a catalytic inhibitor of topoisomerase II for its potential in treating cancer. By inhibiting this enzyme, it can disrupt the cancer cells' ability to replicate their DNA, thereby hindering their growth and proliferation.
Used in Psoriasis Treatment:
ETHYLIMINUM is used as a therapeutic agent for psoriasis, a chronic skin condition characterized by the rapid buildup of skin cells. Its topoisomerase II inhibitory properties can help regulate the overproduction of skin cells, providing relief from the symptoms of psoriasis.
Used in Uveitis Treatment:
ETHYLIMINUM is used as a treatment option for uveitis, an inflammation of the uvea, which is the middle layer of the eye. Its ability to inhibit topoisomerase II can help reduce inflammation and alleviate the symptoms associated with uveitis.

InChI:InChI=1/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)

Downstream Products

• 98631-87-9 1,2-bis(4-acetoxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98632-24-7 1,2-bis(4-methoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98631-95-9 sobuzoxane 
• 98632-15-6 1,2-bis(4-benzoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98631-93-7 Phenyl-acetic acid 4-[2-(3,5-dioxo-4-phenylacetoxymethyl-piperazin-1-yl)-ethyl]-2,6-dioxo-piperazin-1-ylmethyl ester 
• 98632-33-8 1,2-bis(4-m-toluoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98632-10-1 1,2-bis(4-cinnamoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98632-34-9 C₂₈H₃₀N₄O₈ 
• 98632-28-1 1,2-bis(4-phenoxycarbonyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 105622-93-3 4,4'-(1,2-ethanediyl)bis<1-(N-phenylcarbamoyloxymethyl)-2,6-piperazinedione> 
• 98632-16-7 1,2-bis(4-o-fluorobenzoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98632-14-5 1,2-bis(4-o-chlorobenzoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 
• 98632-04-3 (2-Chloro-phenyl)-acetic acid 4-(2-{4-[2-(2-chloro-phenyl)-acetoxymethyl]-3,5-dioxo-piperazin-1-yl}-ethyl)-2,6-dioxo-piperazin-1-ylmethyl ester 
• 98632-17-8 1,2-bis(4-o-methoxybenzoyloxymethyl-3,5-dioxopiperazin-1-yl)ethane 

Relevant articles and documents

Bis diketopiperazines

A pharmaceutical composition useful for aiding regression and palliation of cancer in mammals comprises a therapeutically effective amount of a compound of formula EQU1 wherein R1 and R2 are each separately selected from hydrogen and methyl or together represent an ethylene bridging group, with the proviso that when both of the groups R1 and R2 are methyl they are disposed in the meso configuration, or a non-toxic salt thereof with a physiologically acceptable inorganic or organic acid, in combination with a physiologically acceptable diluent or carrier.