1506-53-2

Basic information

• Product Name: N-DODECYLACRYLAMIDE
• Synonyms: N-DODECYLACRYLAMIDE;N-Laurylacrylamide;N-dodecylprop-2-enamide;2-Propenamide,N-dodecyl-;N-Dodecylacrylamide
• CAS NO: 1506-53-2
• Molecular Formula: C₁₅H₂₉NO
• Molecular Weight: 239.4
• EINECS: 216-136-0
• Mol File: 1506-53-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 58 °C
• Boiling Point: 155 °C / 1mmHg
• Flash Point: 229.74 °C
• Appearance: /
• Density: 0.864 g/cm³
• Vapor Pressure: 8.41E-06mmHg at 25°C
• Refractive Index: 1.452
• PKA: 15.03±0.46(Predicted)
• CAS DataBase Reference: N-DODECYLACRYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-DODECYLACRYLAMIDE(1506-53-2)
• EPA Substance Registry System: N-DODECYLACRYLAMIDE(1506-53-2)

Safety Data

• Hazardous Substances Data: 1506-53-2(Hazardous Substances Data)

Usage

General Description

N-dodecylacrylamide is a chemical compound with the molecular formula C16H31NO and a molecular weight of 257.43 g/mol. It is an acrylamide derivative and is classified as a nonionic surfactant. N-dodecylacrylamide is commonly used in the production of polymers and as a building block for the synthesis of various polymeric materials. It is also employed in the formulation of personal care products, such as shampoos and conditioners, as well as in the manufacturing of adhesives, coatings, and lubricants. N-dodecylacrylamide is known for its ability to reduce surface tension and enhance wetting and spreading properties in various industrial and consumer applications. Additionally, it is considered to be relatively safe for use in these products, with low toxicity and minimal potential for skin irritation.

InChI:InChI=1/C15H29NO/c1-3-5-6-7-8-9-10-11-12-13-14-16-15(17)4-2/h4H,2-3,5-14H2,1H3,(H,16,17)

Upstream product

• 124-22-1 n-Dodecylamine 
• 292638-85-8 acrylic acid methyl ester 
• 79-10-7 acrylic acid 
• 814-68-6 acryloyl chloride 
• 112-16-3 n-dodecanoyl chloride 
• 79-06-1 2-propenamide 
• 2651-43-6 3-hydroxypropionamide 
• 128-37-0 2,6-di-tert-butyl-4-methyl-phenol 
• 15438-67-2 (3-methoxypropyl)amide 
• 143-15-7 1-dodecylbromide 

Downstream Products

• 274904-26-6 (E)-3-(4-{2-[4-((E)-2-Dodecylcarbamoyl-vinyl)-phenyl]-2-oxo-acetyl}-phenyl)-acrylic acid tert-butyl ester 
• 274904-56-2 3-(4-{4-[4-((E)-2-tert-butyloxycarbonyl-vinyl)phenyl]-5-[4-(2-dodecylcarbamoyl-vinyl)phenyl]-1H-imidazol-2-yl}phenyl)-isoxazole-5-carboxylic acid ethyl ester 
• 1018998-77-0 C₅₂H₈₈N₆O₆ 
• 1018998-79-2 C₆₇H₁₁₇N₇O₇ 
• 1018998-81-6 C₈₂H₁₄₆N₈O₈ 
• 1018998-83-8 C₈₉H₁₆₉N₉O₇ 
• 1018998-89-4 C₈₉H₁₆₉N₉O₇ 
• 1018998-95-2 C₈₈H₁₆₉N₉O₅ 
• 1093682-78-0 1-(p-methoxybenzyl)aziridine-2-(N-n-dodecyl)carboxamide 
• 1093682-75-7 1-benzylaziridine-2-(N-n-dodecyl)carboxamide 
• 619-73-8 4-nitrobenzyl chloride 
• 62-23-7 4-nitro-benzoic acid 

Relevant articles and documents

Reactivity of secondary N-alkyl acrylamides in Morita–Baylis–Hillman reactions

The Morita–Baylis–Hillman (MBH) reaction of secondary N-alkyl acrylamides, discarded up to now from investigations of the scope of activated alkenes, was studied. Optimization of the reaction conditions revealed that a balance must be found between activation of the MBH coupling reaction and that of the undesired competitive aldehyde Cannizzaro reaction. Using 3-Hydroxyquinuclidine (3-HQD) in a 1:1 water-2-MeTHF mixture provides the appropriate conditions that were applicable to a wide range of diversely substituted secondary N-alkyl acrylamides and aromatic aldehydes, giving rise to novel amide-containing MBH adducts under mild and clean conditions.

Synthesis and refining method of N-alkyl acrylamide

The invention discloses a synthesis and refining method of N-alkyl acrylamide. The synthesis and refining method comprises the following steps: enabling acyl chloride and primary amine to have amination in a solvent A, washing a reaction product, absorbing impurities, decoloring, cooling, and crystallizing to obtain a crude product, recrystallizing the crude product by using a solvent B, decompressing and drying to obtain a target product. By adopting the synthesis and refining method, the conversion rate of acryloyl chloride is 85 percent or more, and the product purity is 98.5 percent or more.

Synthesis of sialic-acid-group-containing lipid derivatives and application of sialic-acid-group-containing lipid derivatives in pharmaceutical preparations

The invention provides sialic-acid-group-containing lipid derivatives which are widely used for particle preparation modification. The structure is disclosed as Formula (1), wherein R1 represents one of -OH, -HNCOCH3 and -NHCOCH2OH; the HN-R2-S segment is from SH-R2-NH2; SH-R2-NH2 is a compound containing primary amino group and mercapto group; the R3 segment is from compounds containing alpha,beta-unsaturated conjugated carbonyl; and the R4 segment is from R4-H which is a compound containing hydroxy or primary amino group. The sialic-acid-group-containing lipid derivatives provided by the invention can be used for surface modification of multiple particle preparations, and endow the modification preparation with the targeted distribution capacity.