150989-05-2

Basic information

• Product Name: (11E,14E)-Icosa-11,14-dienoyl chloride
• CAS NO: 150989-05-2
• Molecular Weight: 326.95
• Mol File: 150989-05-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (11E,14E)-Icosa-11,14-dienoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (11E,14E)-Icosa-11,14-dienoyl chloride(150989-05-2)
• EPA Substance Registry System: (11E,14E)-Icosa-11,14-dienoyl chloride(150989-05-2)

Safety Data

• Hazardous Substances Data: 150989-05-2(Hazardous Substances Data)

Usage

Description

(11E,14E)-Icosa-11,14-dienoyl chloride is an organic compound with a long chain of 20 carbon atoms and two double bonds at the 11th and 14th positions. The "enoyl chloride" suffix indicates the presence of a double bond and a chloride group, making it a useful intermediate in organic synthesis.

Uses

Used in Organic Synthesis:
(11E,14E)-Icosa-11,14-dienoyl chloride is used as a starting material for the synthesis of various organic compounds, including those with pharmaceutical and biological applications.
Used in Pharmaceutical and Biological Applications:
(11E,14E)-Icosa-11,14-dienoyl chloride is used as an intermediate for the synthesis of compounds with potential pharmaceutical and biological properties.
It is important to handle (11E,14E)-Icosa-11,14-dienoyl chloride with care, as it is a reactive chemical that can react vigorously with water and other reactive compounds.

Upstream product

• 2091-39-6 (Z,Z)-11,14-eicosadienoic acid 

Relevant articles and documents

Improved LC-MS method for the determination of fatty acids in red blood cells by LC-orbitrap MS

We report a new method for fast and sensitive analyses of biologically relevant fatty acids (FAs) in red blood cells (RBC) by liquid chromatography mass spectrometry (LC-MS). A new chemical derivatization approach was developed forming picolylamides from FAs in a quantitative reaction. Fourteen derivatized FA standards, including saturated and unsaturated FAs from C14 to C22, were efficiently separated within 15 min. In addition, the use of a recently introduced benchtop orbitrap mass spectrometer under positive electrospray ionization (ESI) full scan mode showed a 2-10-fold improvement in sensitivity compared with a conventional tandem MS method, with a limit of detection in the low femtomole range for saturated and unsaturated FAs. The developed method was applied to determine FA concentrations in RBC with intra- and interday coefficients of variation below 10%.

Vanilloids. 1. Analogs of Capsaicin with Antinociceptive and Antiinflammatory Activity

As part of a program to establish structure-activity relationships for vanilloids, analogs of the pungent principle capsaicin, the alkyl chain portion the parent structure (and related compounds derived from homovanillic acid) was varied.In antinociceptive and antiinflammatory assays (rat and mouse hot plate and croton oil-inflamed mouse ear), compounds with widely varying alkyl chain structures were active.Short-chain compounds were active by systemic administration in the assays mentioned above but they retained the high pungency and acute toxicity characteristic of capsaicin.In contrast, the long chain cis-unsaturates, NE-19550 (vanillyloleamide) and NE-28345 (oleylhomovanillamide), were orally active, less pungent, and less acutely toxic than capsaicin.The potential of these compounds as antiinflammatory/analgesic agents is discussed in light of recent data on the mechanism of action of vanilloids on sensory nerve fibers.