151074-89-4

Basic information

• Product Name: (S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid
• Synonyms: (S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid
• CAS NO: 151074-89-4
• Molecular Weight: 288.303
• Mol File: 151074-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid(151074-89-4)
• EPA Substance Registry System: (S)-4-Cyano-2-methyl-2-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butyric acid(151074-89-4)

Safety Data

• Hazardous Substances Data: 151074-89-4(Hazardous Substances Data)

Upstream product

• 151124-11-7 (+)-(6S,7S)-7-Methyl-7-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one 
• 151074-83-8 (+)-(2S)-Methyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-3-oxopropanoate 
• 134627-50-2 (6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one 
• 151074-87-2 (+)-(2S)-Methyl 2-methyl-4-cyano-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>butanoate 

Downstream Products

• 48047-95-6 α-methyl-L-ornithine 

Relevant articles and documents

Asymmetric Synthesis of α-Alkyl-α-amino Acids from Chromium-Carbene-Complex-Derived β-Lactams

Optically active bicyclic β-lactam 3 was synthesized by photolysis of optically active oxazolidine carbene chromium complex 1 with oxazine 2.Conversion of the oxazolidine to the oxazolidinone gave a bicyclic β-lactam readily α-alkylated.Cleavage of the alkylated β-lactam gave optically active ester aldehyde 7, which was converted to a number of optically active α-alkyl-α-amino acids.These include (R)-α-methylserine, (S)-α-methylglutamic acid, (S)-α-methylornithine, (S)-vinylalanine, (S)-ethynylalanine, and (S)-2-methyl-2,3-diaminopropionic acid.